HEИндивидуална стипендия2023–2025

FATE-SA · Fate of sulfonamides in wetland systems by multi-element stable isotope concept

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-10-01 → 2025-09-30
Финансиране от ЕС: 211 755 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Разграждането на антибиотици от групата на сулфонамидите в изкуствени вланоземни системи се проследява чрез промени в техния изотопен състав. Това помага за подобряване на пречистването на отпадните води и ограничаване на разпространението на антибиотикорезистентни бактерии.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Fate of sulfonamides in wetland systems by multi-element stable isotope concept

Sulfonamide antibiotics (SAs) are essential medicines used in human and veterinary care. However, their widespread use and incomplete removal in conventional wastewater treatment plants lead to their release into the environment. This contamination promotes the development and spread of antibiotic-resistant bacteria and genes, a major global health threat identified by the World Health Organization. Constructed wetlands are a natural, cost-effective technology used to clean wastewater, but the specific processes by which they break down antibiotics like SAs are not fully understood, making it difficult to optimise their design and efficiency. The EU-funded FATE-SA project addressed this critical knowledge gap. Its primary objective was to develop and validate a novel scientific tool to precisely track and quantify the degradation of sulfonamide antibiotics in complex environmental systems like wetlands. The project pioneered the use of a multi-element stable isotope "fingerprinting" technique. The core idea is that as antibiotic molecules break down, the bonds between different atoms (Carbon, Hydrogen, Nitrogen, Sulfur) are broken, subtly changing their isotopic composition. By measuring these changes simultaneously—a first for this class of antibiotics—the project aimed to act as an environmental detective, identifying not only if the antibiotic is degrading but also how and to what extent. The ultimate goal was to provide a robust scientific basis for improving wetland systems, thereby contributing to cleaner water, a healthier environment, and the global fight against antimicrobial resistance.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Antibiotics (AB), their degradation products and the translocation of resistant genes in the environment poses serious health risks to humans, animals and ecosystems (OneHealth concept). Constructed wetlands (CW) have untapped potential to treat wastewater from agriculture, domestic sewage or contaminated water effluents from waste water treatment plant for eliminating AB. However, the overall distribution, persistence and the contribution of different dissipation processes of AB in CW remain mostly unknown. Here, the project aims to identify degradation processes of AB in wetlands by developing a cutting-edge four-dimensional element isotope (13C, 15N, 2H, and 33/34S) approach and concepts to improve CW use worldwide. Sulfonamides (SAs) are selected as representative AB. Methods of isotope-effect free extraction from environmental matrices and isotope analysis will be developed while a conceptual framework will be tested to isotopically identify degradation processes in wetland, including the direct and indirect photolysis with DOM and nitrate and plant degradation in vitro and in vivo, and to further monitor SAs degradation in the field using isotope concepts. This work will open a new paradigm to better understand and follow up the fate of SAs and other emerging micropollutants in wetlands but also for other field conditions. The applicant has a proven record of experience of isotope concept application supported by 6 first authored publications and has developed independent thinking and problem-solving skills during his past scientific study. The host holds both unique infrastructure for stable isotope analysis (GC/EA-IRMS, MC-ICPMS) and the expertise for implementation, evaluation and interpretation and a rich experience for wetland field work. This project is thus based on the genuine combination of expertise of all contributors to gain new knowledge and experience, enabling the applicant to develop his own research path within this emerging field.

Оригинален текст от CORDIS (на английски).

Участници

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisКоординаторФранция