HEИндивидуална стипендия2023–2025

FLUO.OPC · Fluorescence-based optical phase conjugation through scattering media

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-09-01 → 2025-08-31
Финансиране от ЕС: 195 915 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

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Накратко на български

Светлинните сигнали от флуоресцентни обекти се използват за насочване на светлината през гъсти биологични тъкани. Това помага за подобряване на оптичната микроскопия и по-прецизно маркиране на клетки при дълбоки тъкани.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Fluorescence-based optical phase conjugation through scattering media

The ability to generate and control light through complex media such as thick biological tissue is essential for optical microscopy and many biomedical applications. However, strong scattering within such media severely limits our capacity to manipulate light. Recent advances in wavefront shaping have made progress in addressing this challenge, but these methods rely on coherent laser light and thus cannot be applied to fluorescence, which underpins modern microscopy techniques. Expanding the ability to focus or deliver light to multiple or extended fluorescent targets would greatly broaden the range of applications, particularly in deep-tissue optogenetics, where fluorescent probes enable precise and targeted labeling. This project aims to achieve active control of light propagation through scattering media by exploiting fluorescence signals from fluorescent objects. By combining advanced holographic techniques to extract information from fluorescence with optical phase conjugation, the project seeks to demonstrate that light can be accurately focused through thick, highly scattering media guided by fluorescence.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Generating a complex optical excitation pattern through biological tissue is of great importance for non-invasive biomedical studies. However, for many biological applications, our ability to control light is greatly limited by multiple scattering and physiological motions. While optical phase conjugation has potential to overcome these challenges, techniques based on fluorescence are still at an immature stage, requiring a single isolated guide star. Exploiting multiple or extended fluorescent guide stars will greatly benefit a wide range of applications, such as deep tissue optogenetics, because of the availability and targeted labeling of fluorescent probes. The goal of this proposal is to achieve active control of light through scattering media using multiple or extended fluorescent guide stars via advanced holographic technique and optical phase conjugation, and test its viability for biological tissue.

Оригинален текст от CORDIS (на английски).

Участници

SORBONNE UNIVERSITE · ParisКоординаторФранция