HEИндивидуална стипендия2023–2025

DBSBOT · Deep brain stimulation based on the wireless magnetically localised and ultrasonically actuated micro-robot

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-04-01 → 2025-03-31
Финансиране от ЕС: 173 847 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Безжични микророботи, управлявани магнитно и чрез ултразвук, се разработват за стимулиране на мозъка при заболявания като Паркинсон и Алцхаймер. Те могат да заменят имплантираните електроди, което намалява хирургичните рискове и опасността от инфекции.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Deep brain stimulation based on the wireless magnetically localised and ultrasonically actuated micro-robot

Neurological disorders, such as Alzheimer's and Parkinson's diseases, have become one of the most pressing health problems in the world. Traditional therapies like Deep Brain Stimulation (DBS) rely on invasive, wired systems that pose risks of infection and tissue damage. To address these limitations, this project aims to develop a pioneering solution: wireless, biocompatible microrobots for minimally invasive DBS. These microrobots use magnetic fields for precise navigation within the brain’s cerebrospinal fluid and ultrasound - powered piezoelectric materials to deliver electrical stimulation, bypassing the need for implanted electrodes. The project aligns with the EU’s Brain Research Strategy, which utilizes innovative technologies to advance understanding and treatment of neurological diseases. By integrating robotics, material science, and biomedical engineering, the microrobots aim to reduce surgical risks, improve patient quality of life, and lower healthcare costs.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The application of deep brain stimulation (DBS) is a significant neurosurgical breakthrough that allows targeted circuited-based neuromodulation, which can directly measure pathological brain activity and deliver adjustable stimulation for the management of neurological and psychiatric disorders correlated with dysfunctional circuitry. Traditional DBS systems, as the standard of care in Parkinson's disease, essential tremor and dystonia, are developed based on the cardiac field, including an intracranial electrode, an extension wire and a pulse generator, with advances in engineering and imaging technologies in the past two decades. However, these devices are typically centimetre-scale, which increases the risk of haemorrhage, infection and damage during the treatments. Instead, the small and remotely powered systems may result in less invasive neuromodulation. Therefore, the proposed research aims to develop a novel micro-robot that can implement deep brain stimulation by using the piezoelectric effect induced by ultrasound stimulation in the cerebral spinal fluid. The proposed biocompatible robot can achieve less invasive neuromodulation and precise positioning by using the wireless external magnetic field.

Оригинален текст от CORDIS (на английски).

Участници

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV · MUNCHENКоординаторГермания