HEИндивидуална стипендия2023–2025

OraPickering · Effective co-delivery of therapeutic peptides and intestinal permeation enhancers using a double Pickering emulsion oral delivery system

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-06-01 → 2025-05-31
Финансиране от ЕС: 214 934 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

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Накратко на български

Специални двойни емулсии се тестват за транспортиране на терапевтични пептиди, като инсулина, през стомаха до червата. Това би позволило замяната на инжекциите с по-лесен и евтин прием на лекарствата чрез устата.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Effective co-delivery of therapeutic peptides and intestinal permeation enhancers using a double Pickering emulsion oral delivery system

Therapeutic peptides (TPs) are one of the fastest growing classes of pharmaceuticals with clinical applications in cancer therapy, hormonal or immune disorders, and infectious or metabolic diseases. The number of approved TPs is rapidly increasing, however, to date the vast majority of TPs (> 90%) rely on administration via injections, e.g., insulin, whereof half even need to be administered intravenously and are therefore limited to the clinical environment. This considerably affects patient wellbeing and compliance, as well as treatment costs and ease of distribution. Oral delivery of TPs provides an alternative administration route that is straightforward, cheap, and highly accepted by patients and clinicians. However, the oral administration of TPs is limited by I) the proteolytic gastric and intestinal environments which are detrimental for TPs and II) limited permeation of TPs across the intestinal epithelium. Double water-in-oil-in-water emulsions are of interest as potential oral delivery systems as they allow the encapsulation and co-delivery of hydrophilic and hydrophobic compounds such as TPs and permeation enhancers, respectively. Particularly emulsions stabilized by solid particles, known as Pickering emulsions, have proven promising for the formation of gastric stable emulsions. The goal of OraPickering was to establish Pickering double emulsions as novel oral delivery systems for co-delivery of hydrophilic TPs and hydrophobic permeation enhancers, towards more safe, cheap, and compliant administration of TPs like insulin. The main objectives of OraPickering were 1) to find stable formulations for Pickering double emulsions, 2) test the stability of emulsions and encapsulated TPs under gastric conditions, and 3) confirm their efficacy for intestinal delivery in in vitro cell models.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Therapeutic peptides (TPs) are one of the fastest growing classes of therapeutics with clinical applications in severe and/or chronic diseases like cancer therapy, hormonal or immune disorders, and infectious or metabolic diseases. To date, most TPs can only be administered by invasive injection, which greatly influences treatment costs as well as patient compliance and wellbeing, as e.g. diabetic patients rely on regular insulin injections. Oral delivery of TPs poses a convenient alternative to circumvent these problems, but it is highly challenged by I) the harsh gastric environment detrimental to TPs and II) the poor permeability of the intestinal epithelium to TPs. To tackle these problems, I propose a novel oral delivery system for TPs based on a unique gastric stable Pickering double emulsion, which is able to I) protect TPs from degradation in the gastric environment and II) co-deliver hydrophilic TPs and hydrophobic permeation enhancers (PEs) to the absorption site; the intestinal epithelium surface. Simultaneous co-delivery of TPs and PEs is crucial, but not often achieved. As key deliverables, OraPickering will establish Pickering double emulsions for the encapsulation of hydrophilic TPs and hydrophobic PEs, explore their stability under gastric conditions, and confirm their efficacy and safety for intestinal TP delivery in vitro and in vivo. To implement OraPickering I will join forces with Prof. Nielsen from UCPH, combining my background in material and interface sciences with her expertise in TP delivery and intestinal permeation models and mechanisms. I consider this the ideal environment for my further career development, to learn relevant techniques for drug delivery and gain further experiences to emerge as an independent group leader. In summary, OraPickering provides a novel avenue for oral TP delivery, and thereby contributes to a more facile, safe, and cost-effective administration of TPs in the future.

Оригинален текст от CORDIS (на английски).

Участници

KOBENHAVNS UNIVERSITET · KOBENHAVNКоординаторДания