HEИндивидуална стипендия2023–2025

HiDDyn-AF · High-resolution Decryption of Left Atrial Haemodynamics in Atrial Fibrillation (HiDDyn-AF)

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-10-01 → 2025-09-30
Финансиране от ЕС: 210 963 €
Участници: 2
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Динамиката на кръвния поток в левия предсърдие при предсърдно мъждене се анализира чрез компютърни модели и медицински изображения. Това помага за по-точното разпознаване на биомеханични маркери, свързани с образуването на кръвни съсиреци и риска от инсулт.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

High-resolution Decryption of Left Atrial Haemodynamics in Atrial Fibrillation (HiDDyn-AF)

The project aimed to improve understanding of left atrial (LA) and left atrial appendage (LAA) haemodynamics in atrial fibrillation (AF), a major contributor to cardioembolic stroke. Current clinical imaging modalities cannot fully resolve intracardiac flow structures or wall shear stress patterns, limiting risk stratification and personalised treatment planning. The overarching objective was to develop and validate multi-modal, patient-specific computational models that combine high-resolution CT anatomy with in vivo 4D flow MRI–derived motion and boundary conditions. This integrated approach sought to provide more accurate simulations of LA haemodynamics and identify biomechanical markers linked to thrombus formation.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Atrial fibrillation (AF) is characterized by disorganized atrial electrical activation leading to a rapid and irregular heart rate. Incidence rates are rising to epidemic levels with aging populations. AF disrupts left atrium (LA) fluid dynamics, increasing the risk of stroke and catheter ablation seeks to restore sinus rhythm. We aim to develop of personalised risk stratification in AF patients, begin to optimise ablation treatment and generate novel findings about the pathophysiology of AF. High-resolution Decryption of Left Atrial Haemodynamics in AF (HiDDyn-AF) adopts a cross-disciplinary approach to combine computational fluid dynamics (CFD), 4D flow MRI, late-gadolinium enhancement MRI and computed tomography to create a novel model of LA flow. This model will be applied to investigate AF patients pre- and post-ablation. Furthermore, LA flow will be compared with myocardial fibrosis and strain. Previously, LA flow has been modelled in small groups with idealised or patient-specific geometries. Some applied wall motion however none have been validated with 4D flow MRI as planned in HIDDyn-AF. The project will further extend the state-of-the-art by analysing many more cases than previous studies (N=50), to produce impactful results. The research questions are built on the complimentary experience of the host team, clinical collaborators, secondment team and the applicant. Accordingly, the objectives are to: develop a novel, high-resolution, validated model of LA flow (O1), define LA haemodynamics (vortices, WSS and turbulence) for AF (O2) and determine: the haemodynamic impact of ablation (O3), if haemodynamics predict recurrence of AF (<1 yr) (O4), if a relationship exists between LA myocardial fibrosis (O5), myocardial strain (O6) and haemodynamics. HiDDyn-AF consists of 6 work packages: project management, knowledge transfer & training, model development study, large cohort study of pre- & post-ablation patients, analysis & synthesis and dissemination.

Оригинален текст от CORDIS (на английски).

Участници

SORBONNE UNIVERSITE · ParisКоординаторФранция
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA · BolognaИталия