HEИндивидуална стипендия2023–2025

EnviBrain · Characterization of Diffuse Glioma tumors’ chemical exposome and potential positive associations with environmental pollution through air particulate matter analysis and wastewater based epidemiology

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-11-01 → 2025-10-31
Финансиране от ЕС: 181 153 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Химичните вещества в тъканите на мозъчни тумори (дифузни глиоми) се сравняват с замърсителите в въздуха и отпадните води в Барселона. Това помага да се разбере дали вредните частици от околната среда могат да достигнат до мозъка и да допринесат за развитието на рак.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Characterization of Diffuse Glioma tumors’ chemical exposome and potential positive associations with environmental pollution through air particulate matter analysis and wastewater based epidemiology

Chemicals are essential to modern life, yet their widespread use results in continuous release into the environment. People in urban areas are especially exposed to complex mixtures of contaminants through air, water, food, and consumer products. Increasing evidence suggests that these mixtures may contribute to chronic diseases, including cancer, but specific links between environmental exposures and disease remain poorly understood. This issue is particularly relevant for diffuse gliomas, the most common malignant brain tumors in adults. These cancers have very poor prognosis, and with fewer than 5% of cases having a family history, environmental factors are suspected to play a major role. Despite this, the chemical exposome of human brain tumors has never been systematically investigated. EnviBrain aimed to address this challenge by applying advanced exposomics to brain tumor tissue for the first time. The project had three main objectives: 1. Characterize the chemical exposome of diffuse glioma tissues using a unique patient cohort, providing the first in-depth analysis of chemicals accumulated in human brain tumors. 2. Analyze the chemical composition of airborne particulate matter (UFPs, PM₁, PM₁₀) across Barcelona and assess whether ultrafine particles may act as carriers of hazardous chemicals capable of reaching the brain. 3. Assess population-wide chemical exposure through wastewater epidemiology and explore overlaps with chemicals detected in brain tissues. By integrating state-of-the-art analytical chemistry with data-driven exposomics, EnviBrain aimed to reveal which environmental chemicals people are exposed to, how these chemicals vary across particle sizes and locations, and whether airborne contaminants may accumulate in the brain. The project’s findings reinforce the scientific foundation for EU strategies on chemical safety, zero pollution, and public health, supporting the development of more targeted measures to reduce hazardous chemical emissions and environmentally driven disease risks.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Although chemicals enable a constant improvement of health, life quality and facilitate food production, industrial applications and advanced agricultural practices, their release into the environment may be followed by increased risks for human health. Humans (directly or indirectly) are exposed to a diverse mixture of chemicals through multiple pathways, which has been acknowledged to play an important role in common chronic diseases, including multiple types of cancer, but the specific exposure-disease associations have not been explored sufficiently in many cases. This is particularly relevant for brain tumors, whose causes are still unknown, and it is suspected that the environmental components may play an important role since less than 5% of patients have a family history. Diffuse gliomas are the most common primary malignant brain tumors in adults with poor prognosis and survival, therefore, identifying environmental contributions to diffuse gliomas development and investigating links with chemical exposures is crucial for improving prognosis and treatment options. The objectives of this fellowship are (i) to explore the chemical exposome (exogenous chemicals and associated metabolites) of brain tumor tissues by making use of a unique historical cohort of diffuse gliomas patients (Bellvitge Glioma Cohort; Hospital de Bellvitge; 2005-present) and (ii) assess the exposure of Barcelona citizens to a mixture of contaminants through the analysis of air particulate matter, wastewater and sewage sludge. State-of-the-art analytical chemistry techniques and data science methods will be integrated to identify potential toxic organic chemicals and their metabolites/transformation products in the environment, that may influence the development of diffuse glioma in Barcelona. The generated results can be used by competent authorities to establish more surgical measures to reduce the emission of very hazardous chemicals and improve both air quality and population health.

Оригинален текст от CORDIS (на английски).

Участници

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridКоординаторИспания