HEИндивидуална стипендия2023–2025

LIGHTSUPGEL · Towards unravelling self-assembly/disassembly mechanisms of photo-switchable supramolecular gels by super-resolution microscopy and their use for drug crystallization

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2023-10-01 → 2025-09-30
Финансиране от ЕС
181 153 €
Участници
1
Схема
HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Светлинночувствителните супрамолекулни гелове се изследват чрез суперразрешаваща микроскопия, за да се разбере как променят структурата си под въздействието на светлина. Това помага за разработването на по-ефективни методи за контролиране на меката материя и кристализиране на лекарства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Towards unravelling self-assembly/disassembly mechanisms of photo-switchable supramolecular gels by super-resolution microscopy and their use for drug crystallization

Light-responsive soft materials are attracting increasing interest because they can reorganise their structure when exposed to specific wavelengths of light. Such materials have potential uses in microfabrication, sensing, adaptive surfaces and controlled crystallisation. However, progress in this area has been hindered by the lack of experimental tools capable of visualising, with sufficient precision, how these materials reorganise during light-induced transformations. Without such tools, it is difficult to understand the mechanisms that govern their behaviour or to design next-generation light-controlled materials with improved performance. The LIGHTSUPGEL project was created to address this challenge. Its overall objective was to develop new methodologies to observe, understand and control how supramolecular gels respond to light. By combining advanced microscopy, photochemistry, computational modelling and soft-matter research, the project aimed to generate fundamental knowledge and experimental strategies that could serve as a basis for future technologies involving light-controlled materials. The project pathway to impact centred on improving scientific understanding and enabling more efficient, contactless and energy-saving approaches to structuring and manipulating soft matter. In the long term, the results are expected to contribute to scientific and technological developments in fields such as materials science, photonics, microfabrication and crystallisation science.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The overarching scientific goal of the LIGHTSUPGEL study is to design and synthetize novel reversible photo-switchable azobenzene and bis(urea)-based supramolecular gels, and to develop a super-resolution microscopy-based methodology to visualize the self-assembly and disassembly process in real-time with the aim of unravelling their underlying mechanisms. The cutting-edge combination of super-resolution STED and FLIM microscopies, together with environment-sensitive fluorescent probes, will be employed to spatially controlled photo-switch the gelation and de-gelation, and for first time, simultaneously monitor the process with nanoscopic resolution. Furthermore, the application of this new knowledge and novel photo-switchable gels in gel-mediated drug crystallization, will be explored. The possibility of light-triggered drug crystal harvesting photo-switchable gels offers, will be the first ever described non-invasive and reversible method to harvest crystals from gels. This new technology will mean a huge advance in the field of gel-phase drug crystallization, bringing it closer to its industrialization. By completing this ambitious multidisciplinary work, the applicant will be in an excellent position to create cross-disciplinary collaborations with research groups and industry across Europe and to becoming an independent researcher himself.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз