HEИндивидуална стипендия2023–2025

NANOINHALE · Polypeptide hybrid nanoparticles for the delivery of inhalable drugs

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-04-03 → 2025-04-02
Финансиране от ЕС: 199 694 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Полипептидни наночастици от аминокиселини и захари се тестват за пренос на лекарства директно до белите дробове или изгаряния. Те помагат за преодоляване на биологични бариери като слузта, което прави лечението на инфекциите по-ефективно и безопасно.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Polypeptide hybrid nanoparticles for the delivery of inhalable drugs

Delivering medicines directly to the site of infection can make treatments more effective and reduce side effects. One promising way to achieve this is by using nanoparticles, tiny carriers that can transport drugs deep into the lungs or into wounds when combined with gels. For respiratory infections such as tuberculosis, inhalable nanoparticles could deliver drugs directly to the lungs where they are needed most. Similarly, for burn wounds, nanoparticles embedded in gels can steadily release healing drugs at the site of injury. However, developing such drug carriers is challenging. The particles must be stable, release drugs at the right rate, and break down safely in the body. They must also overcome biological barriers such as mucus, biofilms, and tissue structures that often block medicines from reaching their targets. This project focused on creating new polypeptide-based nanoparticles made entirely from natural building blocks of amino acids and sugars. These materials are biocompatible, biodegradable, and easy to modify, allowing drugs to be attached or released in controlled ways. The nanoparticles are designed to penetrate mucus and target infected cells, making them especially suitable for use in nebulisers or in gel-based wound treatments. In the long term, this research aims to develop a versatile platform technology that could be adapted for treating a wide range of infectious diseases more effectively and safely.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Infectious respiratory diseases such as COVID or tuberculosis (TB) still have devastating effects on population health. While the development of potent vaccines has drastically reduced infection rates for some diseases, medicinal drugs remain a corner stone of treatment. Respiratory drug delivery via inhalation is considered an ideal way to directly target the site of infection in the lung. However, suitable functional polymeric drug carriers meeting all clinical and pharmaceutical requirements are rare. NanoInhale aims to develop novel polypeptide nanoparticles with mucus penetrating and cell targeting properties suitable for nebuliser-based drug administration to the lower respiratory tract with a project proof-of-concept demonstration for tuberculosis (TB) up to in vitro level. This clinically informed project is placed at the intersection of polymer chemistry, biomaterial science, and drug delivery and further expands into the fields of medical devices and nanomedicine. The project involves academic and clinical collaborators active in the fields of polymer and pharmaceutical science as well as TB Immunology. The applicants’ expertise in translational polymeric biomaterials in medical applications will be further enhanced by a unique training programme in scientific and complementary skills. NanoInhale’s impact goes beyond the studied area of TB as this platform technology is envisaged to be exploitable in other respiratory treatments. Project results will be communicated to the scientific community as well as the public to create further awareness of the importance of combating infectious respiratory diseases.

Оригинален текст от CORDIS (на английски).

Участници

ROYAL COLLEGE OF SURGEONS IN IRELAND · DUBLIN 2КоординаторИрландия