HEИндивидуална стипендия2023–2025

SENSiTRANS · Visible-light-activated transmembrane transport by photosensitized isomerization of stiff-stilbene based anion receptors

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2023-09-01 → 2025-08-31
Финансиране от ЕС: 187 624 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Транспортът на отрицателно заредени частици (аниони) през клетъчните мембрани се изследва чрез използването на специални молекули, активирани от видима светлина. Това е важно, защото видимата светлина прониква по-добре в тъканите и е по-безопасна от ултравиолетовата.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Visible-light-activated transmembrane transport by photosensitized isomerization of stiff-stilbene based anion receptors

The control of anion transport across membranes is essential for many biological processes. Several stimuli-responsive artificial anion transporters have been developed in recent years. Many of these transporters rely on light-stimulated isomerization, but a major limitation is their dependence on ultraviolet (UV) light, which limits applicability due to low tissue penetration and potential damage. The objective of this fellowship was to develop a strategy to achieve the isomerization of stiff-stilbene anion transporters in lipid bilayers using visible light, a more practical alternative. The approach relied on a photosensitization strategy. The project combined the researcher’s expertise in organic synthesis with advanced training in supramolecular chemistry, photophysics and transmembrane transport studies at the host institution. The scientific pathway was structured into three research objectives: (1) to sensitize the isomerization of stiff-stilbene photoswitches in solution and lipid bilayers, (2) to achieve visible-light–activated anion transport across membranes, and (3) to explore strategies for active ion transport.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Stimuli-responsive transmembrane anion transport proteins are essential for cellular life due to their implication in important biological functions. Supramolecular systems with analogous properties have been developed, however, most of them rely on the use of damaging UV light. SENSiTRANS is an ambitious and multidisciplinary project aimed at activation of anion transporters using visible light by means of a sensitization strategy. The project focuses on the employment of photosensitizers able to trigger isomerization of stiff-stilbene based receptors in the lipid bilayer, allowing activation of passive transmembrane transport. In addition, insertion of the photosensitizer in a vectorial manner into the lipid bilayer will be explored towards light-driven active transport. The project will result in i) the development of a new strategy to control transmembrane transport with transformative impact in the field of molecular photoswitches and anion receptor chemistry, ii) preparation and growth of the fellow towards a fully independent academic career (the new scientific research skills, complementary soft skills and scientific connections she will acquire will provide her with the necessary competencies to access an academic position at an European institution), and iii) benefit from her multidisciplinary scientific background and her scientific network by the hosting group.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITEIT LEIDEN · LeidenКоординаторНидерландия