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HEДокторантска мрежа2024–2027

REBONE · End-to-end multidisciplinary optimal design for improved personalized bioactive glass/ceramic bone substitute implants

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2024-01-01 → 2027-12-31
Финансиране от ЕС
2 512 688 €
Участници
15
Схема
HORIZON-TMA-MSCA-DN

Линиите свързват координатора с партньорите.

Накратко на български

Персонализирани импланти от биоактивно стъкло и керамика се разработват чрез 3D принтиране и компютърно моделиране, за да пасват точно на анатомията на пациента. Това помага за по-добрата интеграция на имплантите в тялото и намалява нуждата от повторни операции.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

End-to-end multidisciplinary optimal design for improved personalized bioactive glass/ceramic bone substitute implants

Large bone defects caused by trauma, disease, or ageing represent a growing clinical challenge in Europe, particularly in an ageing population. Current treatments heavily rely on bone grafts taken from the patient or donors, which are limited in availability and may cause complications. At the same time, conventional off-the-shelf implants often fail to match the patient’s specific anatomy and mechanical needs, leading to poor integration or long-term failure. ReBone addresses these challenges by developing a new end-to-end approach for personalized bone substitute implants made of bioactive glass and ceramic materials. The project brings together materials science, biomechanics, biology, computational modelling, and clinical planning to design implants that are not only patient-specific in shape, but also tailored in their internal structure, mechanical behaviour, and biological performance. ReBone’s overall objective is to create a predictive and integrated design workflow, starting from clinical imaging data and ending with optimized, manufacturable, and biologically validated bone implants, while training ten doctoral candidates with multidisciplinary approaches and intersectoral interactions. By combining advanced 3D printing technologies, in-silico simulations, and realistic laboratory testing, ReBone aims to reduce trial-and-error in implant design and accelerate translation toward safer and more effective treatments. In the longer term, this approach can reduce revision surgeries, improve patient recovery, and support EU priorities in personalised medicine, advanced manufacturing, and sustainable healthcare innovation.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The musculoskeletal system is extremely vulnerable to ageing and traumatic events, and common clinical conditions often exert a high burden on the clinical system. For patients requiring bone-substitute implants to treat critical-size bone defects, new solutions are required for meeting important unmet needs: personalised solutions for better clinical outcomes; improvements in materials to ensure higher mechanical reliability without compromising bioactive and bioresorbable properties; optimised manufacturing technologies for materials and products of high reliability and quality.REBONE is a four-year doctoral network that aims to innovatively train a new generation of researchers to develop a multidisciplinary optimisation process to provide technologies for 3D-printed personalised bone replacement implants based on bioactive ceramics. The ultimate scientific goal is to construct a platform of computational tools that will enable clinical experts to produce customized bone graft substitutes for the treatment of critical-size bone defects. This innovation will ensure that an ideal treatment solution is found on a patient-specific basis in terms of: i) mechanical and mechano-biological performance, ii) surgical implantability, and iii) manufacturing process reliability. Furthermore REBONE will develop state-of-the-art in silico models based on advanced computational methods and advanced characterisation and validation techniques to obtain personalised implants with a surgical planning visualization system in mixed reality with the following characteristics: i) tailored and reliable mechanical and physical properties; ii) best osteointegration capability; iii) targeted mechanical, physical and mechano-biological functions with patient-specific constraints taking into account the load-bearing anatomical location. Four selected clinical cases will be used as demonstrators of the optimization design and manufacturing process.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз