HEИндивидуална стипендия2024–2026

GLEE · Glycosylation strategy in bio-hybrid Light Emitting diodEs

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период: 2024-07-01 → 2026-06-30
Финансиране от ЕС: 173 847 €
Участници: 1
Схема: HORIZON-TMA-MSCA-PF-EF

Линиите свързват координатора с партньорите.

Накратко на български

Биохибридните светодиоди се подобряват чрез добавяне на захарни молекули към флуоресцентните протеини. Това помага за повишаване на тяхната стабилност при висока температура и светлина, което води до създаването на по-ефективни осветителни устройства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Glycosylation strategy in bio-hybrid Light Emitting diodEs

Explanation of the work carried out by the beneficiaries and overview of the progress Objectives: The project has achieved all the objectives and milestones for this period. In fact, some additional experiments for sections that were originally planned for later months were performed obtaining promising results that will be explained below. The goals of this project were: 1) To performed a glyco-protection to enhance FP stability by new synthetic protocols of first glyco-artificial FPs and glyco-polymeric matrices. 2) To set relationships between sugar modification and thermal-/photo- stability to design the best glyco-shell/ends for lighting devices. 3) Next generation of highly stable and efficient high-power on-chip BioHLEDs.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Light-emitting diodes (LEDs) have emerged as the dominant artificial lighting technology due to their stability and efficiency. However, challenges persist with white LEDs, including their reliance on rare-earth materials, and complex/costly recycling processes. To address these issues, research initiatives are focused on developing sustainable color filters using organic phosphors, based on conjugated polymers, organic dyes and fluorescent proteins (FPs), as the next generation of hybrid WLEDs. Among them, biogenic FP-based phosphors (FPs embedded in polymers/nanoparticles) stand up, as their respective bio-hybrid LEDs (BioHLEDs) have recently achieved high efficiencies and stabilities, making them an attractive alternative to conventional WLEDs. A critical challenge in BioHLEDs is enhancing their stability under high-power conditions, which is hindered by excessive heat generation and deactivation of FPs, which is attributed to FP motion induced by high photon flux and efficient heat transfer facilitated by water molecules in the polymer matrix. The Glycosylation strategy in bio-hybrid Light Emitting diodEs (GLEE) project proposes a novel approach to develop water-less FP-polymer phosphors capable of withstanding high photon flux without heat generation and FP deactivation. Inspired by natural osmotic dehydration mechanisms, the project aims to use sugars as desiccation protectants. Under dry conditions, sugars replace interfacial water molecules, reinforcing intra-protein hydrogen bonds, restricting FP motion, and slowing down heat/ deactivation processes. This involves synthesizing/characterizing glyco-artificial FPs (GAFPs) and glyco-polymeric matrices (GPMs) for BioHLEDs. Through chemo-selective glycosylation, GAFPs will be created with various sugar stabilizers to enhance their thermodynamic/irradiation stability. Additionally, GPMs will be developed to shield FPs from water molecules, enhancing H-bonding interactions, and inhibiting FP motion/deactivation.

Оригинален текст от CORDIS (на английски).

Участници

TECHNISCHE UNIVERSITAET MUENCHEN · MuenchenКоординаторГермания