ComeInCell · Condensates at Membrane Scaffolds – Integrated Systems as Synthetic Cell Compartments

Линиите свързват координатора с партньорите.

Накратко на български

Цел на проекта

ComeInCell will establish a novel integrated Synthetic Cell platform to provide cost- and resource-efficient, environmentally friendly, widely applicable and quantitative model systems to elucidate key cellular mechanisms of health and disease based on the integration of condensate and membrane models. Understanding membrane-condensate interactions is vital for deciphering their functional roles in cellular processes. Our consortium employs synthetic vesicles as model systems to explore these interactions. These tailor-made mimics of cellular compartments offer a platform for studying membrane dynamics and the impact of compartmentalization on the activity of reaction networks and the assembly of complex machinery. We will design synthetic cells as life-science prototyping tools to decipher the role of membrane-associated condensates in essential cellular processes linked to membrane transport, membrane transformation, metabolic networks, and repair. The network will confront global challenges, providing solutions in drug development, therapeutics, green-related issues, and synthetic biology. Our goal is to equip junior scientists with cross-disciplinary expertise for developing integrated synthetic cellular testbeds encompassing condensates and membranes, revolutionizing prototyping systems. We will train the next generation of biophysicists, biochemists and bioengineers in rigorous quantitative and mechanistic thinking, while establishing strong ties to young and emerging European SMEs in the health sector for efficient dissemination towards new therapies

Оригинален текст от CORDIS (на английски).

Участници

• MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV · MUNCHENКоординаторГермания
• AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridИспания
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisФранция
• Dewpoint Therapeutics GmbH · DresdenГермания
• ECOLE NORMALE SUPERIEURE DE LYON · LyonФранция
• HEINRICH-HEINE-UNIVERSITAET DUESSELDORF · DusseldorfГермания
• IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE · LondonОбединеното кралство
• INM - LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH · SaarbrueckenГермания
• INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA · KlosterneuburgАвстрия
• IONERA TECHNOLOGIES GMBH · FreiburgГермания
• KATHOLIEKE UNIVERSITEIT LEUVEN · LeuvenБелгия
• KOBENHAVNS UNIVERSITET · KOBENHAVNДания
• LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN · PlaneggГермания
• MD USE INNOVATIONS SL · SANTIAGO DE COMPOSTELAИспания
• NANION TECHNOLOGIES GMBH · MUNCHENГермания
• RIJKSUNIVERSITEIT GRONINGEN · GroningenНидерландия
• Refeyn GmbH · BerlinГермания
• STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN · UtrechtНидерландия
• STICHTING RADBOUD UNIVERSITEIT · NijmegenНидерландия
• Springer Nature AG & Co. KGaA · BerlinГермания
• TECHNISCHE UNIVERSITEIT DELFT · DelftНидерландия
• TEL AVIV UNIVERSITY · Tel AvivИзраел
• THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEОбединеното кралство
• The Company of Biologists Ltd · CambridgeОбединеното кралство
• UNIVERSIDAD COMPLUTENSE DE MADRID · MadridИспания
• UNIVERSIDAD DE SANTIAGO DE COMPOSTELA · Santiago De CompostelaИспания
• UNIVERSITA DEGLI STUDI DI SIENA · SienaИталия
• UNIVERSITAET POTSDAM · PotsdamГермания
• UNIVERSITAT DES SAARLANDES · SaarbruckenГермания
• UNIVERSITY OF SURREY · GuildfordОбединеното кралство

Връзки

• Виж в CORDIS
• DOI: 10.3030/101168939
• https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e516686595&appId=PPGMS