DANIO-ReCODE · DANIO-CODE - the next frontier: Decoding transcription regulation in regeneration by advanced genomics and computational tools
„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“
- Период
- 2024-11-01 → 2028-10-31
- Финансиране от ЕС
- 2 785 637 €
- Участници
- 20
- Схема
- HORIZON-TMA-MSCA-DN
Линиите свързват координатора с партньорите.
Накратко на български
Генетичните механизми за възстановяване на сърцето, мозъка и очите се изучават чрез модела на зелената рибка. Разбирането на тези процеси може да помогне за повишаване на регенеративния потенциал при бозайниците.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
The principal objective of DANIO-ReCODE is to provide world-class doctoral training to a new generation of early-career researchers interested in understanding the complex and multilayered process of tissue regeneration. DANIO-ReCODE will combine the multidisciplinary expertise of 15 research laboratories at renowned EU and UK scientific institutions to unravel the regulatory mechanisms of heart, brain, and eye regeneration by employing the unique and highly tractable zebrafish model system. Unlike humans, teleosts can repair damaged tissues or even regrow entire appendages. In mammals, regeneration is rare, limited to skin, liver, and toes. Regenerative medicine, however, promises to restore tissue function via the use of stem cells, tissue engineering, and the production of artificial organs, with its importance being recognised as one of the EU strategic missions. A fundamental gap of knowledge is the understanding of the shared and distinct regulatory mechanisms defining regeneration in highly regenerative species and those with lower regeneration potential such as mammals. Since the vertebrate gene complement is highly conserved, applying the knowledge of regeneration mechanisms from non-mammalian models such as zebrafish could identify genetic underpinnings, which when manipulated in mammals, could strongly boost the mammalian regenerative potential. DANIO-ReCODE will thus nurture a cohort of exceptional doctoral candidates and turn them into interdisciplinary experts in computational and developmental biology, providing comprehensive training that spans experimental work, bioinformatics, visualisation, and industry applications. Through the integration of state-of-the-art genomics, computational, and data visualisation techniques, DANIO-ReCODE will result in an enhanced understanding of molecular determinants implicated in vertebrate regenerative processes while providing new avenues for the repair or replacement of damaged or diseased tissues and organs.
Оригинален текст от CORDIS (на английски).
Участници
- AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MadridКоординаторИспания
- CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL · KielГермания
- EARLHAM INSTITUTE · NORWICHОбединеното кралство
- EBERHARD KARLS UNIVERSITAET TUEBINGEN · TuebingenГермания
- IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE · LondonОбединеното кралство
- INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH · WienАвстрия
- KARLSRUHER INSTITUT FUER TECHNOLOGIE · KarlsruheГермания
- LABENA trgovina, svetovanje in proizvodnja laboratorijske opreme d.o.o. · LjubljanaСловения
- LUXENDO GMBH · HEIDELBERGГермания
- MOGRIFY LIMITED · CambridgeОбединеното кралство
- RUDER BOSKOVIC INSTITUTE · ZagrebХърватия
- THE UNIVERSITY OF BIRMINGHAM · BirminghamОбединеното кралство
- UNIVERSIDAD PABLO DE OLAVIDE · SevillaИспания
- UNIVERSITAT DE VALENCIA · ValenciaИспания
- UNIVERSITAT LINZ · LinzАвстрия
- UNIVERSITAT WIEN · WienАвстрия
- UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN · LübeckГермания
- UNIVERSITY OF EAST ANGLIA · NorwichОбединеното кралство
- UNIVERZA V LJUBLJANI · LjubljanaСловения
- UPPSALA UNIVERSITET · UppsalaШвеция
Връзки
Данни: CORDIS, © Европейски съюз