GabaLoco · Unraveling the role of spinal GABApre neurons in presynaptic modulation during locomotion
„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“
- Период
- 2025-06-01 → 2027-05-31
- Финансиране от ЕС
- 226 421 €
- Участници
- 1
- Схема
- HORIZON-TMA-MSCA-PF-EF
Линиите свързват координатора с партньорите.
Накратко на български
GABApre невроните в гръбначния стълб регулират работата на двигателните неврони, например при ходене. Разбирането на тези механизми помага за разработването на нови терапевтични подходи за подобряване на двигателното поведение.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Presynaptic modulation is a cornerstone of neural function, shaping everything from basic motor control to sensory processing and motor learning. It is a powerful mechanism that allow the fine tuning of a neuron selected target through an axonal modulation. In the spinal cord, this potent modulation is mediated by ""GABApre"" neurons. However, although widely studied ex-vivo, their function during naturalistic behaviors remains poorly understood due to technical challenges limiting in vivo access to spinal neurons. By leveraging advanced methodologies, such as in vivo electrophysiological recordings with Neuropixel probes during naturalistic locomotion, this project aims to uncover mechanisms that have so far remained elusive. Combining genetic manipulation, viral targeting, and high-resolution 3D kinematic analysis, this project will investigate the activity of GABApre neurons and their impact on motoneuron dynamics and locomotor performance across movement phases and muscle recruitment. Additionally, we will explore the recently observed dual effect of GABApre neurons and determine whether they consist of distinct subpopulations and whether they exhibit distinct context-dependent functions. By examining GABApre function during natural locomotion, this work will bridge the gap between previous non-physiological studies and the real-world relevance of presynaptic modulation, offering new insights into sensorimotor integration and adaptive motor behavior. While fundamental, this project’s discoveries will provide a crucial foundation for the design of innovative therapeutic approaches.""
Оригинален текст от CORDIS (на английски).
Участници
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS · ParisКоординаторФранция
Връзки
- Виж в CORDIS
- DOI: 10.3030/101211219
- https://ec.europa.eu/research/participants/documents/downloadPublic?documentIds=080166e528b3799f&appId=PPGMS
Данни: CORDIS, © Европейски съюз