MX-WOUND · Transforming chronic wound care with targeted MXene-based antibacterial and regenerative technologies

Линиите свързват координатора с партньорите.

Накратко на български

Цел на проекта

The MX-WOUND project aims to revolutionize chronic wound care by developing a first-of-its-kind multimodal antibacterial and regenerative platform powered by MXene nanotechnology. Conventional treatments are increasingly ineffective due to multidrug-resistant infections and insufficient regenerative support. MX-WOUND addresses these challenges by uniting targeted antibacterial therapy, photothermal modulation, and regenerative stimulation into a single, clinically translatable solution.MXenes, a cutting-edge class of 2D transition metal carbides and nitrides, will be polydopamine-coated and conjugated with MRSA-specific antibodies to ensure highly selective bacterial targeting. Combined with near-infrared light-triggered photothermal therapy, this approach enables rapid pathogen eradication with minimal damage to surrounding tissues. In parallel, electrospun and hybrid-spun nanofibrous scaffolds will be engineered to deliver mesenchymal stem cell-derived secretome, promoting angiogenesis, immune modulation, and tissue repair to accelerate wound closure.MX-WOUND unites leading academic, clinical, and industrial partners from Europe, Ukraine, and the USA in a highly interdisciplinary network. The project follows a rigorous translational pipeline—MXene synthesis and functionalization, scaffold fabrication, in vitro validation, and preclinical in vivo testing—ensuring robustness, scalability, and clinical relevance.Beyond scientific innovation, MX-WOUND will train a new generation of researchers through cross-sectoral secondments, industry placements, and mentoring. By integrating nanotechnology, precision photothermal therapy, and regenerative medicine, MX-WOUND will deliver a transformative, antibiotic-free therapy for chronic wounds, improve patient outcomes, and help combat the global threat of antimicrobial resistance.

Оригинален текст от CORDIS (на английски).

Участници

• LATVIJAS UNIVERSITATE · RIGAКоординаторЛатвия
• FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV · MunchenГермания
• INSTYTUT IMMUNOLOGII I TERAPII DOSWIADCZALNEJ IM LUDWIKA HIRSZFELDA PAN · WROCLAWПолша
• MATERIALS RESEARCH CENTER · KievУкрайна
• MB SENSOGRAFA · VilniusЛитва
• NANOSPACE TECHNOLOGY SRO · MostЧехия
• SUMY STATE UNIVERSITY · SUMYУкрайна
• UNIWERSYTET IM. ADAMA MICKIEWICZA WPOZNANIU · PoznanПолша
• VILNIAUS UNIVERSITETAS · VilniusЛитва
• WORCESTER POLYTECHNIC INSTITUTE · WorcesterСъединени щати

Връзки

• Виж в CORDIS
• DOI: 10.3030/101299634