EstroPatch · Continuous Estrogen Monitoring Patch
„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“
- Период
- 2027-01-01 → 2029-12-31
- Финансиране от ЕС
- 321 301 €
- Участници
- 2
- Схема
- HORIZON-TMA-MSCA-PF-GF
Линиите свързват координатора с партньорите.
Накратко на български
Разработва се лепен с микроигли за непрекъснато измерване на нивата на естроген в кожата, например при проследяване на бременност или менструален цикъл. Това позволява по-лесен и безболезнен мониторинг на хормоните извън болничните условия, което помага за по-ефективни медицински решения.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Estrogen monitoring is crucial across genders for tracking conditions like infertility (1 in 6 globally), breast/uterine cancers, postpartum depression, and schizophrenia. Endocrine cancers are rising in the EU (>100,000 neuroendocrine tumor cases, 60% at late stage), with endocrine-disrupting chemicals contributing significantly. Current estrogen monitoring methods are effective but invasive, hospital-based, and dependent on bulky instrumentation, making regular monitoring challenging. Therefore, there is a vital need to develop a highly sensitive, user-friendly wearable biosensing platform for continuous, on-site estrogen monitoring to ensure effective medical decision-making. Electrochemical biosensors offer high sensitivity and rapid response, making them ideal for wearable estrogen monitoring. Microneedle-based systems enable reliable, minimally invasive hormone detection through direct access to dermal interstitial fluid. This proposal aims to develop, for the first time, EstroPatch—a wearable patch for real-time, continuous monitoring of estrone, estradiol, and estriol levels in dermal interstitial fluid by integrating microneedles, electrochemical sensing, microfluidics, and wireless communication. This will address the current lack of microneedle-integrated systems for estrogen detection. In this project, I propose a multiplexed estrogen monitoring system spanning 0.1–5000 pg/mL using electrochemical sensing with optimized detection and quantitation limits. By integrating microneedles, I aim to develop EstroPatch as a pain-free, easy-to-use, and cost-effective solution for applications such as pregnancy monitoring, menstrual cycle tracking, and cancer treatment.
Оригинален текст от CORDIS (на английски).
Участници
Връзки
Данни: CORDIS, © Европейски съюз