SHINE-Vax · Smart Hydrogel Microneedle Patches for mRNA Nanoparticle Vaccination
„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“
- Период
- 2027-09-01 → 2029-08-31
- Финансиране от ЕС
- 236 340 €
- Участници
- 1
- Схема
- HORIZON-TMA-MSCA-PF-EF
Линиите свързват координатора с партньорите.
Накратко на български
Хидрогелни лепенки с микроигли се разработват за контролирано доставяне на mRNA ваксини, които се освобождават според температурата на тялото. Това може да замени инжекциите, да подобри безопасността и да намали нуждата от строго охлаждане при транспортиране.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
The COVID-19 pandemic highlighted the transformative potential of mRNA vaccines, yet their delivery remains confined to intramuscular injections, which cause discomfort, reduce compliance, and rely on cold-chain logistics. Microneedle patches offer a minimally invasive alternative, but current systems mainly provide single-burst, fixed-dose release, limiting safety and efficacy. This project, SHINE-Vax, develops a temperature-responsive hydrogel microneedle system for controlled mRNA vaccine delivery. Dual hydrogel layers with distinct phase transitions enable an initial release pulse at normal body temperature (~37 °C), sustained low-dose diffusion to reinforce immunity, and reversible suppression under fever-like conditions (~39 °C). Encapsulated lipid/polymer nanoparticles preserve mRNA integrity and stability, reducing cold-chain dependence. By integrating materials engineering, nanotechnology, and vaccine science, SHINE-Vax will deliver a proof-of-concept prototype (TRL 2–3) demonstrating autonomous, adaptive release. This innovation aims to enhance vaccine efficacy and safety while broadening accessibility, particularly in resource-limited settings, positioning Europe at the forefront of next-generation, patient-friendly vaccination technologies.
Оригинален текст от CORDIS (на английски).
Участници
- KAROLINSKA INSTITUTET · STOCKHOLMКоординаторШвеция
Връзки
Данни: CORDIS, © Европейски съюз