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HEДокторантска мрежа2027–2031

TagTIC · Target mining for the development of therapeutics against pathogen-induced cancers

„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“

Период
2027-01-01 → 2031-12-31
Финансиране от ЕС
4 281 580 €
Участници
23
Схема
HORIZON-TMA-MSCA-DN-JD

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Взаимодействието между микроби като H. pylori и развитието на рак в стомашно-чревния тракт се анализира чрез модели от човешки клетки. Това помага за откриването на нови мишени за лекарства и подобряване на прецизността на лечението при такива пациенти.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Цел на проекта

Gastrointestinal cancers, including gastric and colorectal cancer, are among the most prevalent and lethal malignancies worldwide. Growing evidence highlights the microbial agents Fusobacterium nucleatum, Helicobacter pylori, or Epstein-Barr Virus as prominent key drivers of cancer initiation and progression by disrupting epithelial signaling, promoting chronic inflammation, and evading immune surveillance. However, current therapeutic strategies and model systems rarely address pathogenic tumorigenesis or progression and altered drug efficacy in the presence of these pathogens, leaving a critical gap in the development of precise and preventive treatments.TagTIC addresses this challenge through a systems medicine approach that integrates microbiology, cancer biology, drug discovery, and artificial intelligence. By using innovative preclinical organoid model systems that closely resemble patient conditions, TagTIC aims to decipher complex host-pathogen interactions at single-cell and spatial resolution and to address them therapeutically. Research will focus on: (i) identifying vulnerable molecular nodes involved in pathogen-associated cancers; (ii) developing novel strategies for lead discovery and treatment; (iii) generating and analyzing innovative ex vivo models using 2D/3D cultures, patient-derived organoids, and organ-on-chip technologies. The network will train eleven Doctoral Candidates (DCs) towards translational leaders, capable of analyzing and solving complex biomedical needs with innovative strategies and approaches. DCs will follow a structured training program combining basic and translational science with cross-sectoral exposure to academia and industry. The collaboration between nine beneficiaries and 14 associated partners ensures a strong curriculum, interdisciplinary mentorship, and international mobility to empower DCs for careers in academia, biotech, pharma, and socio-economic sectors across Europe.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз