ChronoBridge · Bridging Chronobiology and Physiology through Expert Training
„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“
- Период
- 2027-01-01 → 2030-12-31
- Финансиране от ЕС
- 3 885 022 €
- Участници
- 18
- Схема
- HORIZON-TMA-MSCA-DN
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Биологичните ритми и метаболизмът в органи като чернодробния и мускулите се анализират чрез клетъчни модели и опити с мишки. Разбирането на тези процеси помага при справянето с хронични заболявания като диабет тип 2 и затлъстяване.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Modern lifestyles disrupt physiological rhythms, contributing to a surge in noncommunicable chronic diseases, yet circadian clock (~24h) driven rhythms and their roles remain poorly understood. The ChronoBridge training network aims to accelerate recognition of the 'time variable' as pivotal for understanding metabolic rhythms in health and disease. Bridging disciplines such as chronobiology, bioinformatics, multi-omics analyses, and physiology, the primary goals of the ChronoBridge training network's are to extend the research base of chronometabolism, establish a sustainable EU network for disseminating chronobiology principles, and advance chronomedicine. Twelve Doctoral Candidates (DCs) will benefit from interdisciplinary career development, leveraging expertise from 18 partners (14 academic, 3 industrial, 1 clinical) and one patient association. The DC projects aim to fill knowledge gaps by investigating metabolic synchronization mechanisms in different organs, understanding their impact in healthy and diseased states, and advancing the preclinical development of chronomedicine. The DC projects will investigate metabolic diseases like type 2 diabetes and obesity using patient-derived cell models from liver, skeletal muscles and adipose tissues; organoids and induced pluripotent stem cells, representing both healthy and disease states; innovative genetically modified mouse models of clock mutants; diet and drug treatments in preclinical models and in humans, and interventions in human liver donors ex vivo. The completion of the ChronoBridge training objectives will enable specialists to incorporate the 'time' dimension into biomedical research, integrate chronobiological expertise into translational projects, and disseminate circadian interventions for health and diseases to broad audiences. ChronoBridge aspires to promote European leadership in chronobiology and chronomedicine, influencing the medical community, patients, the public, and policymakers.
Оригинален текст от CORDIS (на английски).
Участници
- ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE · LausanneКоординаторШвейцария
- Association Maladies du Foie depuis l'EnfanceНиво градФранция
- BGI TECH SOLUTIONS (POLAND) Sp. z o.o. · WarszawaПолша
- BIENTA LIMITED COMPANY · KYIVУкрайна
- BIOTALENTUM TUDASFEJLESZTO KFT · GoedoelloУнгария
- CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES · NantesФранция
- CHARITE - UNIVERSITAETSMEDIZIN BERLIN · BerlinГермания
- HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH · NeuherbergГермания
- INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisФранция
- KAROLINSKA INSTITUTET · STOCKHOLMШвеция
- MAGYAR AGRAR- ES ELETTUDOMANYI EGYETEM · GodolloУнгария
- NANTES UNIVERSITE · NantesФранция
- TECHNISCHE UNIVERSITAET MUENCHEN · MuenchenГермания
- THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE · CAMBRIDGEОбединеното кралство
- UNIVERSITAET zu LUEBECK · LubeckГермания
- UNIVERSITE DE GENEVE · GeneveШвейцария
- UNIVERSITE PARIS CITE · ParisФранция
- UNIVERSITEIT MAASTRICHT · MaastrichtНидерландия
Връзки
Данни: CORDIS, © Европейски съюз