MERIT · MEtabolic Reprogramming in viral pathogenesis: From Infection to Therapeutic innovations
„Хоризонт Европа“ — Действия „Мария Склодовска-Кюри“
- Период
- 2026-10-01 → 2030-09-30
- Финансиране от ЕС
- 4 577 843 €
- Участници
- 19
- Схема
- HORIZON-TMA-MSCA-DN
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Взаимодействието между вирусите и метаболизма на човешките клетки се анализира чрез 3D модели на органи и високоразрешаваща микроскопия. Това помага за разбирането на дългосрочните ефекти от инфекциите и разработването на нови терапевтични стратегии.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
The MERIT consortium aims to shift virology from a traditional virus-centric approach to one that better incorporates host biology. The primary objective of the consortium is to understand the complex interplay between viruses and host cells, with a focus on metabolic reprogramming and the long-term consequences of infection. This will be achieved through an interdisciplinary approach that incorporates three methodological pillars, viz., organotypic models (organoids), integrative and spatial omics, and advanced (super-resolution) microscopy. The organotypic models will serve as miniaturised in vitro models that mimic the human genetic and tissue-specific context, enabling the study of organ-specific processes in viral pathogenesis. Integrative omics will provide a comprehensive understanding of virus-host interactions by combining data from diverse approaches, allowing the dissection of specific mechanisms. Spatial omics will result in the precise localisation of molecular changes within the tissue architecture. Advanced microscopy techniques (super-resolution optical microscopy, label-free 3D tomography, autofluorescence microscopy, and Raman microspectroscopy) will bridge the gap between molecular data and cellular-level events, offering unprecedented visualisation of cells in the tissue context. By integrating these state-of-the-art techniques, the consortium will not only advance fundamental virology research but also contribute to the development of novel therapeutic strategies that address both immediate and long-term impacts of infections. The research's relevance to the MSCA doctoral programme lies in its innovative training approach, which aims to equip researchers with cutting-edge skills to address emerging infectious diseases. The MERIT researchers will take a more holistic approach to virology, thereby ensuring pandemic preparedness and elevating the EU's position in this field.
Оригинален текст от CORDIS (на английски).
Участници
- STICHTING AMSTERDAM UMC · AmsterdamКоординаторНидерландия
- ACADEMISCH ZIEKENHUIS LEIDEN · LeidenНидерландия
- BEONCHIP SL · ZaragozaИспания
- CHIP NANOIMAGING AS · TromsНорвегия
- INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY · TriesteИталия
- Isogen Life Science BV · De MeernНиво градНидерландия
- JUSTUS-LIEBIG-UNIVERSITAET GIESSEN · GIESSENГермания
- KAROLINSKA INSTITUTET · STOCKHOLMШвеция
- MEDIZINISCHE UNIVERSITAT INNSBRUCK · InnsbruckАвстрия
- SINTEF AS · TrondheimНорвегия
- STEMCELL TECHNOLOGIES UK LTD · CAMBRIDGEОбединеното кралство
- STICHTING PROEFDIERVRIJ* DUTCH SOCIETY FOR THE REPLACEMENT OF ANIMAL TESTING · Den HaagНидерландия
- STICHTING SAXION · EnschedeНидерландия
- The Parfum Agency · AmsterdamНиво градНидерландия
- UNIVERSITEIT VAN AMSTERDAM · AmsterdamНидерландия
- UNIVERSITETET I OSLO · OsloНорвегия
- UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET · TromsoНорвегия
- UNIWERSYTET JAGIELLONSKI · KrakowПолша
- Vectory B.V. · AmsterdamНиво градНидерландия
Връзки
Данни: CORDIS, © Европейски съюз