Targeting of retrograde transport vesicles in the endoplasmic reticulum

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Цел на проекта

The secretory pathway of eukaryotic cells comprises several specialized membrane-bound compartments. Transfer of proteins between these compartments is mediated by transport vesicles. A correct targeting of these vesicles is accomplished by interactions between integral membrane proteins on the vesicles and target organelles, termed v-SNAREs and t-SNAREs, respectively. SNAREs required for anterograde transport from the endoplasmic reticulum (ER) towards the plasma membrane are already known. The discovery of a novel t-SNARE on the ER of yeast allows us to investigate for the first time the targeting of retrograde moving vesicles in the secretory pathway. Since both anterograde and retrograde v-SNAREs must be present on the same vesicles, either as targeting molecules or recycling passengers, it is possible that some of the vSNAREs involved in forward transport also have a role in retrograde traffic. The genetic and biochemical studies described in this proposal offer a unique opportunity to determine whether any of the known v-SNAREs act in this way or whether there is a separate set of retrograde vSNAREs to be discovered. Our investigations should contribute to a better understanding of how eukaryotic cells maintain their compartmental organization.

Оригинален текст от CORDIS (на английски).

Участници

• MRC Laboratory of Molecular Biology · CambridgeКоординаторОбединеното кралство
• Not availableНиво градНидерландия

Връзки

• Виж в CORDIS