Synthesis of the c1-c28 fragment of spongistatin 1, a very potent antimitotic cancer cell growth inhibitor
4РП — Обучение и мобилност на изследователи
- Период
- 1997-04-28 → 1999-04-27
- Финансиране от ЕС
- —
- Участници
- 2
- Схема
- RGI
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Синтезът на фрагмент от спонгистатин 1, вещество от морски гъби, се изследва чрез органична химия. Това помага за разбирането на противотуморните свойства на молекулата при рак на белия дроб, мозъка и кожата, тъй като естествените количества на веществото са твърде малки.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Research objectives and content The Spongistatins are a new class of naturally occurring marine metabolites (isolated from the marine sponges Spongia sp. and Spirastella sp. in the early 1970s), the structures of which have been recently disclosed. This new family of macrocyclic lactone polyethers has attracted immediate considerable attention, due to their potent antitumor activity against highly chemoresistant tumor types, such as human melanoma, lung, colon and brain cancers. The low availability of the molecules from the natural sponges is a serious obstacle for biological screening. Therefore, a total synthesis of Spongistatin 1, the most potent molecule of the family has been planned with efforts from two chemical laboratories. The spiroketals, caractheristic units present in Spongistatin 1, will be sinthesized by the methodology develop by the group of Prof. Steven V. Ley, already successfully applied to the construction of several other natural products. The incorporation of a degree of flexibility into the synthesis will permit the preparation of structurally related analogues, which will help in the understanding of the structure/ activity relationship of Spongistatins and their antimitotic properties. Training content (objective, benefit and expected impact) I consider that the University of Cambridge it is now one of the most important European research centers in Organic Chemistry. During my training stay there, under the supervision of Prof. Steven V. Ley, I expect to improve my knowledge and experience in Synthetic Organic Chemistry. At the moment I have carried out research directed to methodologic aspects and would gain very much by working on a total synthesis project. Links with industry / industrial relevance (22) The understanding of the structure/ activity relationship of Spongistatins and their antimitotic properties are of great relevance for medicine and the pharmaceutical industry.
Оригинален текст от CORDIS (на английски).
Участници
- University of Cambridge · CambridgeКоординаторОбединеното кралство
- Not availableНиво градИспания
Връзки
Данни: CORDIS, © Европейски съюз