Splice-site control of a muscle-specific exon of the b-tropomyosine pre- mrna - mechanism of rna secondary structure formation and identification of trans-acting factors

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Цел на проекта

Research objectives and content Various elements have been identified that modulate splice-site selection in alternative splicing events. Among them, pre-mRNA secondary structures have been shown to activate or repress the use of specific splice sites. The b-tropomyosin pre-mRNA has provided an instructive model to study how RNA folding can control alternative splicing site usage. The muscle-specific exon has been shown to be repressed in a non-muscle cell environment by a complex mechanism that involves RNA secondary structure formation. The aim of my project will be to understand the mechanism that induces RNA secondary structure formation and to identify trans-acting factors that allow the switch of the splicing pattern towards the skeletal muscle-specific form during myogenic differentiation. Training content (objective, benefit and expected impact) After having studied RNA structure-function relationship in RNA phages, this project will give me the opportunity to study RNA structure-function in more complex organisms.

Оригинален текст от CORDIS (на английски).

Участници

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISКоординаторФранция
• Not availableНиво градНидерландия

Връзки

• Виж в CORDIS