Original reaction sequence(s) and new linker(s) development(s) in organic solid phase chemistry

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Цел на проекта

Research objectives and content A. Learning the principle of combinatorial synthesis (2 months): Al & A2. Design, Methods & Techniques of combinatorial synthesis. A3 & A4. Combinatorial synthesis in solution vs solid phase A5. Automation & data-processing. B. Planning a combinatorial synthesis (solid Phase Chemistry) (16 months): . B1. Adaptation and optimization of new reaction sequence(s) -including reaction(s) not yet described on solid supports enable subsequently the preparation, in an automated way, of original compound libraries in a format suitable for wide testing (7/8 months): - Choose the reaction sequence(s) allowing the preparation of the target molecules using individual and structurally diverse sets of building blocks. - Define the rection conditions for both the individual reactions and the whole sequence(s) amenable to automation. B2. Selection of a set of representative molecules (diversity measurements, computational approaches involving virtual library(ies), molecular modeling...) in order to maximize the range of application (using commercially available or in-house data-processing softwares) and to identify suitable reaction conditions for a successfull library(ies) synthesis (2/3 months): - Identify a particular set of diverse and sensible building blocks using data-processing softwares in order to get a fine balance the universe of diversity, shape, functional groups distribution and electro-static surfaces. - Define scope and limitations of each individual step of the seuence(s) for a successful library(ies) synthesis. B3. Designing and developing new type(s) of linker(s) most suitable for the reaction sequence(s) previously adapted and optimized on solid supports (6 months). At no time I will be involved in a production team. Training content (objective, benefit and expected impact) A. To participate to an applied research project in a broad, well-integrated, interdisciplinary approach to drug discovery in which chemistry, engineering, biochemistry, molecular biology & screening technology, data-processing expertise must all be coordinated for the best results. B. To increase my knowledge in organic chemistry, biochemistry, analytical methods on solid supports (FT-IR microspectroscopy / gel-Phase & MAS NMR spectroscopy / ES-MS, TOF-MALDI-MS, TOF-SIMS). C. To learn principle of combinatorial synthesis and methods & techniques of solid phase organic chemistry. D. To use commercially available or in-house data-processing softwares for designing libraries and processing, monitoring, interpreting thus generated chemical & biological data. E. One or two full-paper(s) published in good scientific level review(s) and valuable for the whole scientific community. Links with industry / industrial relevance (22) I will be hosted in an interdisciplinary industrial research center (CRLD-Rhone-Poulenc Agro) with a high scientific level, directly involved in developing new technologies.

Оригинален текст от CORDIS (на английски).

Участници

• Rhône-Poulenc Agrochimie SA · LyonКоординаторФранция
• Not availableНиво градИталия

Връзки

• Виж в CORDIS