Molecular mechanisms of retinoid receptor function in pluripotent cells
4РП — Обучение и мобилност на изследователи
- Период
- 1998-02-01 → 2000-01-31
- Финансиране от ЕС
- —
- Участници
- 2
- Схема
- RGI
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Ретиноидите регулират развитието на зародиша, като например чрез активиране на специфични гени в стволови клетки. Анализът на протеина TFIIA помага да се разбере как се стартира този процес и как се контролира генната експресия.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Research objectives and content Retinoids play a fundamental role in regulation of cell proliferation, differentiation and embryonal morphogenesis. Pluripotent embryonal carcinoma (EC) cells differentiate upon retinoic acid (RA) administration and provide a model system to study the RA-regulation of gene expression during early stages of development. Critical for EC cell differentiation is the transactivation of the RARb2 promotervia retinoid receptors (RAR and RXR) binding to RA-responsive elements (RAREs) in close proximity to the TATA-box. I propose to investigate the role of transcription factor TFIIA in RA-dependent signalling pathway through the RARb2 promoter. In the RARb2 promoter TFIIA overlaps with the 3'-RARE. Since binding of the receptor heterodimer to this element is critical for transcriptional activation, it will be important to assess the requirement for TFIIA in RARb2 promoter transactivation. This study will provide insight not only into the role of TFIIA in retinoid dependent signalling in pluripotent cells but also in transcription initiation, in general. Training content (objective, benefit and expected impact) The molecular biology/biochemical approach proposed will be beneficial to the applicant's training, at both theoretical and technical levels, as an independent researcher. Training of young researchers from less favoured regions of the community is likely to have a major impact on their scientific development. Upon return, the applicant will both introduce the advanced technologies and promote possible collaborations. Links with industry/industrial relevance (22)
Оригинален текст от CORDIS (на английски).
Участници
- Katholieke Universiteit Nijmegen - Stichting Katholieke Universiteit · NijmegenКоординаторНидерландия
- Not availableНиво градГърция
Връзки
Данни: CORDIS, © Европейски съюз