Asymmetric synthesis of alpha-amino acids

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Цел на проекта

Research objectives and content The main aim of this project is the study of a-amino acid synthesis using new N-dialkylated diketopiperazine based auxiliaries. In order to investigate the regio- and diastereoselective properties of these auxiliaries we shall initiate a programme of research into six areas: 1) An investigation into the general applicability of a novel deprotonation/reprotonation strategy for the preparation of a wide range of a-amino acids. 2) Determination of what protecting groups can be employed for protection on the amidic nitrogens. 3) Development of a new methodology for the preparation of either enantiomer stereospecifically isotopically labelled a-amino acids. 4) Preparation of a wide range of homochiral a,a-bis-alkylated a-amino acids. 5) We wish to implement investigations into a duplication of chirality protocol in order to replicate a-amino acids. 6) Exploration of the possibility of asymmetric synthesis of A,B substituted amino acids by a novel Michael addition approach. Training conent (objective, benefit and expected impact) I think that I shall be able to acquire new knowledges about other methods of asymmetric synthesis of a wide range of homochiral a-amino acids based on stoichometric chiral auxiliaries which are applicable to large scale synthesis.

Оригинален текст от CORDIS (на английски).

Участници

• THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD · OXFORDКоординаторОбединеното кралство
• Not availableНиво градИспания

Връзки

• Виж в CORDIS