MODULATION OF SIGNAL · Modulation of signalling cascades for the treatment of cancer, diabetes and inflammation
5РП — Човешки потенциал в науката
- Период
- 2002-12-01 → 2006-11-30
- Финансиране от ЕС
- 1 312 614 €
- Участници
- 9
- Схема
- NET
Линиите свързват координатора с партньорите.
Накратко на български
Протеиновите каскади, които регулират процеси като инсулиновия сигнал, се анализират чрез генетични и химични методи. Разбирането на тези механизми помага за определяне на подходящи цели за терапия при рак, диабет и възпаления.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Protein phosphorylation is a control mechanism that regulates most aspects of cell life. About one third of mammalian proteins contain covalently bound phosphate, and it now seems likely that protein kinases, protein phosphatases and their regulatory subunits will comprise several percent of all human gene products. Abnormal protein phosphorylation is a cause or consequence of major diseases, such as arthritis, Morbus Alzheimer, cancer, diabetes, hypertension and stroke, while defects in genes that encode particular protein kinases and phosphatases underlie a number of inherited disorders, including a variety of leukaemias, lymphomas and severe combined immunodeficiency syndromes. Here we focus on three different systems of sequentially regulated protein kinases designated as protein kinase cascades" or "signalling cascades", which are involved in the development of cancer (the mitogen- activated protein kinase cascade - p42/44MAPK cascade), in inflammation (the p38 MAPK- or stress- activated protein kinase - SAPK - cascade) and in insulin signaling (the phosphoinositol-3 kinase/protein kinase B/Glycogen synthase kinase 3 - PI-3K/PKB/GSK3 - pathway). These signaling cascades contain different protein kinases as potential targets for therapeutic approaches. The aim of the proposal is to elucidate the role of the different protein kinases, to understand their molecular mechanisms of regulation and to identify their targets which are responsible for the specific effects by using genetic, biochemical and chemical approaches in combination. As a result, therapeutic targets for the treatment of cancer, inflammatory diseases as well as diabetes will be defined and the suitability of these targets will be analyzed in cell-based assays and model organisms. "
Оригинален текст от CORDIS (на английски).
Участници
- HANNOVER MEDICAL SCHOOL · HANNOVERКоординаторГермания
- BIOMEDICAL SCIENCES RESEARCH CENTRE ALEXANDER FLEMING"" · GLYFADA (ATTIKI)Гърция
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISФранция
- IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE · LONDONОбединеното кралство
- THE UNIVERSITY OF TUEBINGEN · TUEBINGENГермания
- UNIVERSITE DE NICE - SOPHIA ANTIPOLIS · NICEФранция
- UNIVERSITY MEDICAL CENTRE UTRECHT · UTRECHTНидерландия
- UNIVERSITY OF DUNDEE · DUNDEEОбединеното кралство
- UNIVERSITY OF ZURICH · ZURICHШвейцария
Връзки
Данни: CORDIS, © Европейски съюз