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FP5Докторантска мрежа2002–2006Включен след преглед

UBITARGETS · Training network on functional genomics and proteomics of arabidopsis ubiquitin ligases and their targets in signalling

5РП — Човешки потенциал в науката

Период
2002-12-15 → 2006-06-14
Финансиране от ЕС
1 166 119 €
Участници
6
Схема
NET

Линиите свързват координатора с партньорите.

Накратко на български

Протеиновите комплекси SCF и APC/C при растението Arabidopsis регулират стабилността на протеините чрез процеса убиквитиниране. Разбирането на тези механизми помага да се разбере как се контролират клетъчното делене и предаването на сигнали в растенията.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Цел на проекта

After completion of yeast, Arabidopsis, Caenorhabditis, Drosophila and human genome sequences, the next challenging task of biology is to identify the functions of eukaryotic genes and their protein products, which is a prerequisite for future biotechnological applications. Building upon its traditional agricultural links, plant research can now deploy new research tools to functionally characterise the Arabidopsis and rice genomes using proteomics and functional genomics. As the function of genes is ultimately controlled by the stability of their protein products, a central target is to understand how the ubiquitination-dependent proteolysis pathways regulate the stability of proteins. In these pathways, E3 ubiquitin ligases SCF (Skp1-cullin-F-box protein) and APC/C (anaphase promoting complex) are essential to control the stability of regulatory factors involved in signal transduction, transcription and cell division. Due to applications in cancer biology, the study SCF and APC/C is a focus of intense current research. In Arabidopsis, about 2.5% of all proteins represent SCF and APC/C components suggesting that SCF and APC/C mediated proteolysis represents also a central regulatory pathway in plants. The goal of this proposal is to gain a generally applicable information about the function and regulation of conserved components of plant SCF and APC/C complexes. To reach this goal, a network will unite interdisciplinary expertise to study the composition and substrates of SCF and APC/C complexes using protein interaction, biochemical, mass spectrometry, physical and immunological techniques, reverse genetics, transcript profiling and high-through-put genetic engineering. The project aims to reach a break-through in our understanding of the role played by plant SCF and APC/C complexes in the regulation of cell division and signalling.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз