CHECKPOINTS AND CANCER · Checkpoints, DNA damage response and cancer
5РП — Човешки потенциал в науката
- Период
- 2003-01-01 → 2007-06-30
- Финансиране от ЕС
- 1 286 912 €
- Участници
- 8
- Схема
- NET
Линиите свързват координатора с партньорите.
Накратко на български
Механизмите за защита на ДНК при увреждания от радиация или химикали се анализират чрез изучаване на специфични протеини и ензими. Разбирането на тези процеси помага да се разбере как генетичните дефекти водят до нестабилност на генома и развитие на рак.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
The DNA Damage Response (DDR) protects the genome from cytotoxic and mutagenic effects of chemicals and radiation in the environment. Genetic defects in DDR lead to genome instability and predispose individuals to diseases like cancer. DDR is a rapid, dynamic and integrated response to genome insult which co- ordinates cell cycle progression, DNA replication and DNA repair. Our understanding of DDR has been based largely on the use of specific approaches in specific model organisms: e.g. genetics in yeast, biochemistry in frogs, cytology in mammalian cells, etc. The participating teams are experts with these model organisms who are committed to expanding their repertoire of technical and conceptual approaches to studying DDR. Our objectives are:- To characterize mechanisms of genome surveillance in response to DNA damage and DNA replication stress by studying several key components (PI(3)- related kinases and associated subunits, Sgs1 helicasef PCNA and RF-C-related DDR components).- To examine the role of novel Components of the DNA damage signal transduction pathway.- To characterize the downstream effects of DDR on DNA replication, chromatin structure and ubiquit in mediated proteolysis. In each case, a multidisciplinary approach will involve the study of processes and proteins in different organisms using different technical strategies. This unique European collaboration will lead to new advances and contribute to an integrated view of DDR in eukaryotic cells.
Оригинален текст от CORDIS (на английски).
Участници
- CANCER RESEARCH UK · LONDONКоординаторОбединеното кралство
- BEN GURION UNIVERSITY OF THE NEGEV · BEER-SHEVAИзраел
- CANCER RESEARCH UK · LONDONОбединеното кралство
- ERASMUS UNIVERSITEIT ROTTERDAM · ROTTERDAMНидерландия
- INSTITUT CURIE · PARISФранция
- UNIVERSITY OF GENEVA · GENEVEШвейцария
- UNIVERSITY OF SUSSEX · BRIGHTONОбединеното кралство
- UNIVERSITÀ DEGLI STUDI DI MILANO-BICOCCA · MILANOИталия
Връзки
Данни: CORDIS, © Европейски съюз