GENOME STABILITY & C · Linkage between genome stability and checkpoint control
5РП — Човешки потенциал в науката
- Период
- 2002-12-01 → 2005-11-30
- Финансиране от ЕС
- 1 500 000 €
- Участници
- 9
- Схема
- NET
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Връзката между стабилността на генома и контролните механизми при увреждане на ДНК се анализира чрез работата на специфични протеини (хеликази) при дрожди и хора. Разбирането на тези процеси помага да се обясни появата на рак, ускореното стареене и някои невродегенеративни заболявания.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
The preservation of genome stability is an essential process in every living organism. DNA can be damaged by a variety of agents and in a number of ways, often with deleterious consequences to cell survival. To prevent such consequences, DNA damage triggers a multitude of responses in eukaryotic cells, including DNA damage signaling and repair, and delay of cell cycle progression until repair is complete. This latter response is referred to as the DNA damage checkpoint". If this checkpoint fails for any reason, genome instability can result. In higher eukaryotes, this can lead to cancer, accelerated ageing and/or certain neurodegenerative disease states. In this application, a set of complementary genetic and biochemical approaches are proposed for the study of the linkage between genome stability maintenance and checkpoint control. The nine laboratories in the proposed network will use biological systems that will allow the efficient integration of these complementary approaches. The main objectives to be addressed are briefly summarized as follows: - To understand the molecular function of DNA helicases involved in the preservation of genomic stability in yeast and humans. These helicases include S. cerevisiae Sgs 1 p, Srs2p, Dna2p, Mph1p, and the human XPB, XPD, BLM and WRN proteins - To establish how the activity of DNA repair and recombination proteins is controlled by checkpoint proteins The achievement of these objectives will allow the network to define the functions and interactions of the different components of the DNA replication, repair and recombination machineries and to understand the regulatory circuits connecting these processes with checkpoint control. This information is a prerequisite to obtaining a complete insight into cellular growth control and how these controls are modified during tumorigenesis and other disease states. "
Оригинален текст от CORDIS (на английски).
Участници
- University of Cambridge · CambridgeКоординаторОбединеното кралство
- CANCER RESEARCH UK · LONDONОбединеното кралство
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISФранция
- ERASMUS UNIVERSITEIT ROTTERDAM · ROTTERDAMНидерландия
- GEORG-AUGUST-UNIVERSITY GOETTINGEN · GOETTINGENГермания
- HOSPTIAL UNIVERSITARIO DE CANARIAS (HUC) · LA CUESTA DE ARGUIJONНиво държаваИспания
- IFOM FONDAZIONE FIRC DI ONCOLOGIA MOLECULARE · MILANOИталия
- UNIVERSITY OF AARHUS · AARHUS CДания
- UNIVERSITY OF ZURICH · ZURICHШвейцария
Връзки
Данни: CORDIS, © Европейски съюз