MADCD · Molecular analysis of drosophila cell division
5РП — Човешки потенциал в науката
- Период
- 2003-01-01 → 2007-04-30
- Финансиране от ЕС
- 1 196 309 €
- Участници
- 6
- Схема
- NET
Линиите свързват координатора с партньорите.
Накратко на български
Молекулярните механизми на деленето на клетките се анализират чрез модел с плодови мухи, като се изследват центрозомите и процесите на цитокинеза. Това помага за разбирането на генетичната нестабилност и причините за развитието на раковия процес при хората.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Mitotic errors and genome instability are major contributing factors to malignant transformation. Loss or gain of entire chromosomes, or stable chromosome fragments generated by all sorts of rearrangements, play an essential role in the unbalance of gene products that contributes to malignancy. The importance of aneuploidy in the progression of a cell to the cancerous state is well established. Aneuploidy can be generated by defects in either the kinetochore, the mitotic apparatus or the spindle checkpoint. Another mitotic structure that has been implicated in cancer etiology is the centrosome. Centrosome abnormalities have now been reported in many tumors and many oncogenes and tumor suppressor genes have been found to be associated with the centrosome at different stages of the cell cycle. Finally , it has been proposed that multinucleated cells produced by failure of cytokinesis would give rise to aneuploid mitotic products that would promote carcinogenesis The research to be undertaken is aimed at a further understanding of the molecular mechanisms that underlie genomic stability in higher eukaryotes.The aim of this proposal is the study of the above topics using Drosophila melanogaster as a model organism. Using a variety of integrated genetic and biochemical approaches we plan to analyze(1) the spindle checkpoint machinery,(2) the regulation of centrosome activity,(3) the centrosome and its interacting proteins and(4) the mechanisms of cytokinesis. Given the high degree of evolutionary conservation of genes involved in cell division, our findings should provide the basis for identifying genes that govern the mitotic process in human cells. The discovery of such genes should extend our knowledge of cancer etiology and provide a potential basis for therapeutic intervention.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF ROME LA SAPIENZA"" · ROMAКоординаторИталия
- ASSOCIACAO DO INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR · PORTOПортугалия
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISФранция
- CENTRO NACIONAL DE INVESTIGATIONES ONCOLOGICAS · MADRIDИспания
- CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MADRIDИспания
- University of Cambridge · CambridgeОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз