IL-7 AND T CELLS · Roles of IL-7 in the regulation of T cell homeostasis
6РП — Действия „Мария Кюри“
- Период
- 2004-04-01 → 2006-03-31
- Финансиране от ЕС
- 167 055 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Ролята на протеина IL-7 и неговите рецептори се анализира при Т-лимфоцитите, например как ниското им ниво при ХИВ инфектирани води до загуба на клетки. Разбирането на тези механизми помага да се разбере защо имунната система не успява да се възстанови.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Цел на проекта
Interleukin-7 promotes survival and proliferation of lymphocytes both during thyrnic maturation and also in the case of mature peripheral cells. In HTV-infected individuals and in clinical settings, which result in T cell depletion an increase of serum, IL-7 concentration was found. Increased production of IL-7 in response to T cell loss is considered as a homeostatic response mechanism aiming at the restoration of peripheral T cell number. In our previous studies we found a decreased level of IL-7R in HIV-infected patients and the decrease of the receptor was correlated with the level of T cell depletion and also with the increase of serum IL-7 concentrations. These results suggest that low IL-7R expression of T cells may contribute to the loss of T lymphocytes in HIV-infected individuals and may also limit the positive effects of the high IL-7 concentration on T cells.Our research objectives discussed in the proposal are the following:1) Assay the hypothesis that low IL-7R expression of T lymphocytes in HIV positive subjects may result in survival disadvantage for peripheral T lymphocytes. Analyse if known apoptosis regulatory molecules are affected in 1L-7R negative T cells from HIV patients.2) Analyse if dendritic cells (DC) can produce IL-7 and characterise those factors of DC maturation and activation, which regulate IL-7 expression. Test the hypothesis if DC can present IL-7 to T cells by binding the cytokine to the extracellular matrix with a similar mechanism described in the case of bone marrow stromal cells.3) Analysis of the production and functon of the soluble IL-7Ra protein. We plan to screen which cells produce the soluble form of the IL-7R and analyse if the soluble receptor can interfere with the effects of IL-7.4) Analyse if IL-7 plays a role in the regulation of HIV tropism.Our research may open new lines of thinking in field of T cell homeostasis in HIV-infected individuals.
Оригинален текст от CORDIS (на английски).
Участници
- KAROLINSKA INSTITUTET · STOCKHOLMКоординаторШвеция
Връзки
Данни: CORDIS, © Европейски съюз