GMNL2003LACTAM · Atropenantioselective lactamizations using an intramolecular Staudinger ligation strategy
6РП — Действия „Мария Кюри“
- Период
- 2003-11-01 → 2005-10-31
- Финансиране от ЕС
- 149 276 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Методите за създаване на големи пръстеновидни молекули (макролактами) се тестват чрез специфична химична реакция, наречена лигация на Стаудингер. Това помага за разработването на ефективни стратегии за синтезиране на сложни химични структури с определена пространствена форма.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - GMNL2003LACTAM (Atropenantioselective lactamisations using an intramolecular Staudinger ligation strategy)
An intramolecular Staudinger ligation strategy has been disclosed to ring-closed biaryl-type macrolactams. Various ring size of biaryl-macrolactames have been efficiently prepared. In particulary, a 16-membered o,o-dimethyl substituted biaryl containing a medium-sized lactam has been prepared featuring axial chirality as the only asymmetric element. The same product was also prepared using an enantiomerically enriched P-chiral auxiliary but without any detectable asymmetric induction. This researcher has allowed the development of a powerful intramolecular Staudinger ligation strategy to ring-close biaryl-type macrolactams.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The present proposal concerns the development of atropenantioselective localizations using an intermolecular Standing legation strategy. The study will be undertaken in the Homestead/Van Maureen group at the University of Amsterdam. This group has recently disclosed a novel strategy for the synthesis of medium-sized lactase, and is currently developing the use of the /nframolecular Standing legation in difficult localizations, towards an improved synthesis of several homo- and heterodetically closed cyclopeptides. Future work proposed herein will be dedicated to the particularly challenging stereo selective synthesis of cyclopeptides exhibiting atropisomerism. Striking examples of related bioactive products are RP 66453 (neurotensine receptor antagonist) and the glycol part of vancomycin (glycopeptides antibiotic)
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITEIT VAN AMSTERDAM · AMSTERDAMКоординаторНидерландия
Връзки
Данни: CORDIS, © Европейски съюз