RESPONSE · Responsive surface assemblies
6РП — Действия „Мария Кюри“
- Период
- 2004-03-01 → 2005-02-28
- Финансиране от ЕС
- 40 000 €
- Участници
- 1
- Схема
- ERG
Линиите свързват координатора с партньорите.
Накратко на български
Многослойни покрития от биополимери и наночастици се анализират за реакцията им към околната среда, например как хитозанът защитава слузестия слой от почистващи препарати. Това помага за създаването на интелигентни повърхности за контролирано доставяне на лекарства или защита на тъканите.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - RESPONSE (Responsive Surface Assemblies)
The project aimed to understand the build-up process of environmentally friendly polyion-polyion, polyelectrolyte or nanoparticles, multilayers, as well as the responses of these multilayers to ambient stimuli. Multilayer research is important in the area of interfacial engineering since it paves the way to the design of smart surface coatings for a range of applications, including low friction surfaces, anti-soiling applications and targeted and controlled drug delivery and release. It is also of importance for protecting certain biological surfaces such as mucous coatings that are exposed to harsh environments. The primary function of mucus coatings is to protect underlying tissues against environmental insult and desiccation and to provide superb lubrication. It is known that mucins are readily removed from surfaces by surfactants broadly used in personal care products. The results of our study showed that, by building multilayers of mucins with biologically compatible polyelectrolytes, such as chitosans, the affinity of the polylelectrolyte layers to the surfaces could be changed so that the protective mucin layers became resistant to surfactant attack. Thus, a possible way of mucus layer protection was offered.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The goal of the project Responsive Surface Assemblies is to obtain a deep understanding of interfacial multilayer films in terms of their structure, interaction, reorganisation, and response to changes in environmental conditions (pH, ionic strength, sur factant addition). The means to reach the goal is provided by a range of surface chemical techniques such as surface force balances, atomic force microscope, scattering techniques and techniques for adsorption studies. Most of the required techniques are a vailable at the host institution. The project takes advantage of several international collaborators that will provide additional techniques, nanoparticles and novel polyions. The focus is on two research areas. The first one is concerned with the effect o f polymeric and surface active additives on mucin coatings. In particular the formation of protective polymeric layers on mucin-coated surfaces is to be investigated. This has relevance for harmaceutical and oral care applications. The second research area is concerned with multilayer build-up of polyelectrolyte-nanoparticle composites. The traditional layer-by-layer process will be utilised as well as novel approaches utilising in-situ formation of nanoparticles next to polyions. Particular emphasis will be given to direct measurements of the interactions involved in the build-up process, a topic that despite its importance has not been thoroughly investigated. The research is relevant in the general area of structured materials and nano-composites.
Оригинален текст от CORDIS (на английски).
Участници
- KUNGLIGA TEKNISKA HOEGSKOLAN · STOCKHOLMКоординаторШвеция
Връзки
Данни: CORDIS, © Европейски съюз