BIONEMS · Nano-electromechanical systems for biomedical applications
6РП — Действия „Мария Кюри“
- Период
- 2004-06-01 → 2005-05-31
- Финансиране от ЕС
- 40 000 €
- Участници
- 1
- Схема
- ERG
Линиите свързват координатора с партньорите.
Накратко на български
Наномеханични сензори от полимери се разработват за откриване на протеини и единични нишки ДНК. Използването на тези материали вместо силиций повишава чувствителността на устройствата, което позволява по-точно измерване на биологични молекули.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - BIONEMS (Nano-electromechanical systems for biomedical applications)
Nanomechanical sensors fabricated in polymer materials have been developed, characterised and applied for DNA and protein detection. The low Young modulus of polymers, about 40 times lower than that of silicon, enables to improve the sensitivity of the sensor devices for target detection. This allows superior mechanical properties of cantilevers. The devices were applied for measurement of the adsorption of single stranded DNA and proteins. It was demonstrated that, by using polymeric materials, sensitivity was enhanced by a factor of six compared to that of commercial silicon nitride cantilevers. Characterisation of spring constant, resonant frequency and quality factor as a function of the dimensions and the medium allowed concluding a potentially 10 fold higher sensitivity of polymeric cantilever sensors.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The aim of the project will be the development of biochip plailbtms based on micro- and nanotechnology for functional genomics and proteomics. The linai microsystems will be composed of biological nanosensors, optical and electric transducers, microfluidic s and CMOS circuitry for signal processing. Integration of these units will result in both miniaturization of biochip platforms and an increase in the sensitivity of the assays performed. The resulting Nanobiochips will present several advantages, like low reagent consumption, short analysis time, real-time monitoring and high sensitivity. Also, the biological nanosensors will allow direct detection, avoiding the problems associated with fluorescent and radioactive labeling used nowadays. The portable biose nsor microsystem will be mainly applied in the biomedical field, where mobility implies a significant improvement for health monitoring. Among the applications are the detection of combined markers for diagnosis and follow-up of prostate, breast and endome trial cancers. The key element of the biosensor microsystem for specific biological detection will be the nanomechunical response of an array of micro- nanocantilevers. Briefly, the operation principle in pharmacogenctic applications is as follows. Nucleic acids are covalently immobilized on the surface of a micro- nanoeantilever. When the micro- nanocantilevers are exposed to a medical sample, in which a nucleic acid with the complementary nucleotide sequence is present, this will hybridise with (he immobi lized nucleic acid. This will give rise to a change of surface stress and mass of the micro- nanoeantilever that is translated into a nanomechanical response, i.e., a cantilever bending and a change of its resonant properties that can be measured. Also, ch anges in surface stress can be measured directly through integrated piezoresistors in the cantilevers.
Оригинален текст от CORDIS (на английски).
Участници
- CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS · MADRIDКоординаторИспания
Връзки
Данни: CORDIS, © Европейски съюз