BICATORG · Self-hidden Bifunctional Organocatalysts for Organic Synthesis
6РП — Действия „Мария Кюри“
- Период
- 2005-05-01 → 2007-04-30
- Финансиране от ЕС
- 153 072 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Специални органични катализатори, съчетаващи фосфор и бор, се тестват за стабилизиране на реактивни междинни съединения. Това помага за подобряване на активността и селективността при синтеза на нови химични вещества.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - BICATORG (Self-hidden Bifunctional Organocatalysts for Organic Synthesis)
Taking into account the increasing interest for poly-functional compounds combining donor and acceptor moieties, the first objective of this project was to expand the variety of available phosphine-borane derivatives. In this regard, the incorporation of flexible ferrocenyl and diphenylether spacers represented an important achievement. The second objective was to define new fields of interest for these ambiphilic derivatives through their reaction with organic partners. We were particularly interested in evidencing their ability to stabilise reactive intermediates. Accordingly, the o-R2P(Ph)BR'2 skeleton was demonstrated to form a highly stable 'carbene adduct', whose Wittig-type reactivity completely vanished due to strong intramolecular interaction with the Lewis acid. Studying the related nitrene adducts, the intermediate phosphasides were found to be dramatically stabilised as well. Aiming at promoting the nitrogen evolution photochemically, an original coordination isomerisation was observed. Accordingly, ambiphilic derivatives were found to provide general heterodiene scaffolds for new photoisomerisable systems. The third and last objective was to evaluate representative phosphine-borane gold(I) complexes in the catalysis. Preliminary results suggested a subtle interplay between electronic and steric effects. Ongoing work aimed to take advantage of the boron Lewis acid to increase the activity and selectivity compared to catalysts derived from simple phosphines.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The research project aims at developing new tools for synthetic chemistry, more precisely a new class of multi-centre catalysts (MCC). This approach markedly differs from those reported so far since the two active sites of the catalysts would mutually and reversibly protect each other via an intramolecular donor-acceptor interaction. Accordingly, the bifunctional derivatives would behave as self-hidden or dormant catalysts. Thanks to this methodology, a broader range of active sites could be involved and th e efficiency and scope of MCC should therefore be increased. The project will be divided into three consecutive stages: (i) design and synthesis of a few representative bifunctional skeletons, (ii) feasibility evaluation in a powerful C-C bond forming reac tion (the Baylis-Hillman reaction) and (iii) further developments of this concept including an original preparation of epoxides (a variation of the Corey-Chaykovsky reaction). This innovative project has a combination of fundamental and applied aspects. I t fully meets the complementary skills of the applicant researcher (synthetic organic chemistry) and of the host research team (heteroelement chemistry, highly reactive compounds). Due to its interdisciplinary character, this work should be of interest fo r a large community of synthetic chemists. The proposed project intends to complete the scientific training of the applicant, to prepare his own career and to favor the future establishment of european networks. The quality of the infrastructures and scie ntific environment should be emphasized, as well as the scientific and training expertise of the already well-recognized host team. Lastly, the collaboration of young researchers from a different but complementary chemical background should be particularly beneficial.
Оригинален текст от CORDIS (на английски).
Участници
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISКоординаторФранция
Връзки
Данни: CORDIS, © Европейски съюз