STATPAX · IL-7 dependent commitment of lymphoid progenitors to the B cell pathway
6РП — Действия „Мария Кюри“
- Период
- 2005-03-01 → 2007-02-28
- Финансиране от ЕС
- 157 886 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Сигналите от протеина IL-7 определят как стволовите клетки се превръщат в B-лимфоцити, които произвеждат антитела. Разбирането на този процес помага да се разбере механизмът на тежкия комбиниран имунодефицит при хората.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - STATPAX (IL-7 dependent commitment of lymphoid progenitors to the B cell pathway)
B Lymphocytes produce antibodies which are important for humoral immunity. This project integrated the role of IL-7 signalling into our current understanding of the transcriptional control of B cell development. The experiments provided novel and important insights by determining the molecular consequences of IL-7 signalling for early B cell development. The interleukin7 receptor was composed in part by the common gamma chain receptor as well. A common cause of human x-linked severe combined immunodeficiency was caused by a mutation in this common gamma chain receptor. We thus added to our knowledge on how this signalling axis works.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
During the course of evolution, the immune system has developed to defend us against infections by creating a diverse number of specialized cell types. B-lymphocytes are produced by the differentiation of hematopoietic stem cells (HSC) into gradually more lineage-restricted progenitors. This B cell pathway requires the coordinate action of the early transcription factors PU.1 and Ikaros prior to the activation of the B-cell-specific regulators E2A, EBF and Pax5. In addition, interleukin-7 (IL-7) signalling instructs the initial differentiation of B-lymphocytes from the common lymphoid progenitor. This project will investigate how IL-7 signalling, through activation of the transcription factor STAT5, is integrated into the transcriptional control of early B c ell development.
Оригинален текст от CORDIS (на английски).
Участници
- RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY (IMP) · VIENNAКоординаторНиво градАвстрия
Връзки
Данни: CORDIS, © Европейски съюз