TCELLACT-DIABETES · The role Of T Cell activation in type 1 diabetes; T cell differentiation versus T cell tolerance

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Цел на проекта

The proposal presented here represents a continuation of the work I have done in the USA on<p>T lymphocyte peripheral tolerance and autoimmune diabetes. My goal is to gain a better<p>understanding of the disregulation of the mechanisms of immune tolerance leading to the activation of<p>autoreactive T cells in autoimmune processes. This will allow us to rationally design new therapeutic<p>strategies against type 1 diabetes in particular that can prevent or stop the progression of the disease<p>before insulin function is lost. These forms of therapy are inexistent at the present time.<p>The interplay among three types of cells plays an important role in the onset of type 1 diabetes.<p>These are CD8+ T cells, CD4+ T helper cells and antigen presenting cells (APCs). In a normal<p>situation, tolerogenic APCs will pick and transport self-antigens from the parenchyma to the draining<p>lymph nodes where they will silence CD8+ and CD4+ T cells. If CD4+ T cell tolerance fails, CD4+<p>helper cells will activate APCs that in turn will promote the differentiation of potentially autoreactive<p>CD8+ T cells into diabetogenic killer cells. Based on this hypothesis, the aim of this project is to<p>decipher the cellular and molecular interactions responsible for the establishment of T cell tolerance to<p>pancreatic antigens and the activation of potentially autoreactive T cells leading to autoimmunity.

Оригинален текст от CORDIS (на английски).

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• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEКоординаторНиво граднепознат регион

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