NMARIE-ERG-2004 · Characterisation and role of interactions between opioid and cannabinoid systems
6РП — Действия „Мария Кюри“
- Период
- 2005-10-01 → 2006-09-30
- Финансиране от ЕС
- 40 000 €
- Участници
- 1
- Схема
- ERG
Линиите свързват координатора с партньорите.
Накратко на български
Взаимодействията между опиоидната и каннабиноидната системи в мозъка се анализират чрез примери като влиянието на THC върху обезболяването. Разбирането на тези процеси помага за изясняване на механизмите на наркозависимостта и нейните невротоксични ефекти върху здравето.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - NMARIE-ERG-2004 (Characterisation and role of interactions between opioid and cannabinoid systems)
The molecular mechanisms underlying drug addiction processes are poorly understood. However, their understanding is essential both at the fundamental level (study of the functioning of the CNS (Central Nervous System) and the interconnections of neuronal networks) and at the level of public health (addictions being considered as chronic and recurrent diseases). Epidemiological data show that polyconsumption is the most habitual mode of misuse of psychoactive substances and association of different drugs may influence the establishment of an addicted state as well as the neurotoxic effects. In the understanding of addictive processes, cannabinoid and opioid system are of particular importance as they are the targets of two major drugs (cannabis and heroine respectively) and they play a major role in establishment and maintenance of addiction to other drugs (alcohol, cocaine...). So, we initiated a study on interactions between the opioid and cannabinoid systems. We defined them in two types: direct (oligomerisation of opioid and cannabinoid receptors) or indirect (interactions between the signal transduction pathways). Concerning the indirect interactions, we are currently characterising a cell model to study how cannabinoid receptor could induce enkephalins (endogenous ligand of opioid receptor involved in addiction processes) release. Using behavioural experiments, we found that the potentiating effect of delta-9-THC (psychoactive compound of cannabis) on opioid-mediated analgesia could involve a third partner: the cholecystokinin system underlying the complexity of addiction processes. Considering the data we obtained, we plan to continue the characterisation of our cell model and decipher the interrelation we pointed out between cannabinoid, opioid and cholecystokinin system.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Although drug abuse and addiction are really problematic in EU, only few data are available concerning the cell mechanisms that govern these processes. Hence, this research project consists in deciphering these mechanisms in the context of polydrug abuse, because it will study the interactions between opioid and cannabinoid system. Two types of interactions will be considered: direct and indirect. The first one is defined as a putative oligomerisation of cannabinoid CB1 and opioid mu receptor after chronic or acute treatment with cannabinoids and opioids, including morphine and delta-9-THC (delta-9-tetrahydrocannabinol: the psychoactive compound of cannabis).Moreover, the consequences of oligomerisation on the receptor signal transduction will be investigated. The second type of interactions, defined as an interaction between the signalling pathways, will study the mechanisms involved in the enkephalins release by the delta-9-THC. These projects will involve expertise in cell biology and in cell signalling, brought by the researcher and expertise in behavioural pharmacology and in addiction processes brought by the host laboratory. Indeed, it will allow an easy reintegration of the researcher. Moreover, all the experiments in this project would help us to achieve a better understanding of the interactions between opioid and cannabinoid systems, and especially their plasticity during chronic treatment as observed with addicted people.
Оригинален текст от CORDIS (на английски).
Участници
- CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · PARISКоординаторФранция
Връзки
Данни: CORDIS, © Европейски съюз