EURODESY · A European research training site for the design and synthesis of novel Neuroprotective and Hypoglycaemic Agents through a multi-disciplinary approach
6РП — Действия „Мария Кюри“
- Период
- 2006-02-01 → 2010-01-31
- Финансиране от ЕС
- 984 122 €
- Участници
- 1
- Схема
- EST
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Нови химични съединения, като антиоксиданти и производни на глюкозата, се разработват за борба с диабета тип 2 и невродегенеративни заболявания. Тези проучвания помагат за създаването на по-ефективни и селективни лекарства за лечение на тези състояния.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - EURODESY (A European research training site for the design and synthesis of novel neuroprotective and hypoglycaemic agents through a multi-disciplinary approach)
EURODESY set the basis for a research training site for the development of new potentially therapeutical agents of major socio-economic importance. It was supervised by the researchers of the Institute of Organic and Pharmaceutical Chemistry at the National Hellenic Research Foundation (NHRF), and financed by the Marie Curie Actions EST. The programme provided research training to 10 Early Stage Researchers (ESR) in the design, synthesis and biological assessment of novel antioxidants, neurosteroids and cannabinoids that will be both potent and selective for the prevention and treatment of specific neurodegenerative diseases, and also glucose-thiosemicarbazones and glucopyranosylamine derivatives as potential drugs for type 2 diabetes (T2D) therapy. It was achieved by integrating multidisciplinary fields encompassing synthetic organic, organometallic, pharmaceutical chemistry, computational chemistry, X-ray crystallography, biophysics and biological assessment. Research training involved personal supervision by the host research staff, courses and practicals, a well-structured programme of seminars, the organisation of two workshops, and presentation skills through presentation of the ESR work in local and international conferences as well as in workshops and seminars. In addition to 48 peer reviewed articles in conference proceedings, the research results were published in 29 peer reviewed articles in international journals (two of which are still under evaluation), plus 2 manuscripts in preparation, 2 peer reviewed chapters in books, 1 national patent and 5 other publications. One of the former ESR fellows obtained the PhD diploma, which was characterised as 'outstanding', a second fellow submitted the PhD Thesis awaiting defence date, and a third PhD Thesis is under preparation. In addition to the two former ESRs waiting for their PhD Theses evaluation, one of them is looking for a permanent job in her home country, two of them are currently post-doctoral fellows and five of them continue their career as PhD students in several universities / research institutes. Detailed information for the research training activities are provided in the next sections and in the appropriate annexes indicated therein. The programme established the basis for gaining projects within the FP7, e.g. two REGPOT projects are currently running to our institute, 2 ITN projects have been sumbitted.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
EURODESY focuses on establishing a European Research Training site for the development of new agents for potential therapeutic intervention in neurodegenerative diseases and type 2 diabetes mellitus.The project aims to provide research training in the design and synthesis of novel antioxidants, neurosteroids, and cannabinoids, as neuroprotective agents, and thiosemicarbazones, 1,2,4-oxadiazoles of b-D-glucose derivatives and indole-imidazole hybrids, as potential hypoglycaemic drugs.This will be achieved by integrating multi-disciplinary fields encompassing synthetic organic and pharmaceutical chemistry, X-ray crystallography, biophysics, biological assessment and computational chemistry, in a joint effort under an efficient management structure.EURODESY objectives will be supported by the researchers at the National Hellenic Research Foundation (NHRF) in an attempt to develop a new generation of multi-skilled, and highly qualified scientists. Trainees will be equipped with multidisciplinary outlook and skills in order to shape the future of European research excellence in academia and industry.They will be trained in synthetic methodologies of organic, pharmaceutical and organometallic chemistry and in X-ray crystallographic, biophysical, biological and computational methods with the aim of facilitating the design and synthesis of new chemical entities as potential drugs. This training will be reinforced by familiarisation with industrial procedures for the manufacture of pharmaceuticals.The integration o f this multidisciplinary expertise within the NHRF will significantly enhance its existing scientific output in pharmaceutical development and health and strengthen its competitive position as a European centre of excellence in research areas of major socio-economic importance.
Оригинален текст от CORDIS (на английски).
Участници
- NATIONAL HELLENIC RESEARCH FOUNDATION · ATHENSКоординаторНиво градГърция
Връзки
Данни: CORDIS, © Европейски съюз