NORHC · Nuclear organisation in the regulation of Hox gene clusters
6РП — Действия „Мария Кюри“
- Период
- 2006-04-01 → 2007-09-30
- Финансиране от ЕС
- 159 046 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Движението на водородните протони в специфичен керамичен материал (бариев церат с итрий) се анализира чрез неутронно разсейване. Това помага да се разбере защо материалът губи способността си да провежда електричество при температури над 600 градуса Целзий.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - NORHC (Nuclear organisation in the regulation of Hox gene clusters)
INS data of the protons has been collected and also data of the perovskite lattice itself. Upon introduction of H into the BCY sample clear bands appear in the higher energy regions and these modes are undoubtedly connected to H modes in the system. Contrary to the common picture of H in the BCY being part of an OH bond, only very weak peak is seen in the energy transfer corresponding to an OH stretching mode (around 400 meV). Various aspects of the proposed research have been dealt with in the last 24 months. By themselves they cannot yet point definitely towards a specific model of H motion in yttrium-doped barium cerate. Referring back to the introduction, the current data show overall that this particular perovskite system cannot provide significant proton conductivity at temperatures beyond 600 degrees Celsius, due to dehydration. However, more pieces of information need to be collected and the contribution of simulation is emphasised, but also coupling the neutron scattering measurements to mass measurements to give a clear idea about the hydrogen content under any given combination of temperature and humidity.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The correct temporal and spatial patterns of gene expression of Hox genes are necessary for patterning of the developing embryo. Intriguingly, the time and place of Hox gene expression is collinear with the order of the genes on the chromosome. However, t he molecular mechanisms underlying this exquisite gene regulation are poorly understood. In cell culture, the sequential activation of mouse HoxB genes correlates with a visible unfolding of chromatin structure, and a re-localisation of active genes within the nucleus. I want to understand the mechanisms that underpin these large-scale changes in chromatin and nuclear organisation, by combining fluorescence in situ hybridisation (FISH) with mouse models of Hox gene regulation. To do this I will firstly identify cis-acting genomic elements that regulate the nuclear reorganisation of HoxB. I also propose to ask whether other Hox clusters behave similarly, by analysing the nuclear behaviour of HoxD in vivo, in the embryo. These experiments should provide mechanistic insight into colinear gene expression.
Оригинален текст от CORDIS (на английски).
Участници
- MEDICAL RESEARCH COUNCIL · LONDONКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз