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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
FP6Докторантска мрежа2005–2009

GLYCOGOLD · Exploration of the nature and potential of Glyco-nano-particles

6РП — Действия „Мария Кюри“

Период
2005-04-01 → 2009-03-31
Финансиране от ЕС
2 327 423 €
Участници
14
Схема
RTN

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Златни наночастици, покрити със захари, се използват за проучване на взаимодействията между биомолекулите в клетките. Тези структури помагат за по-доброто разбиране на биологичните процеси и подобряват насочването на лекарства и диагностиката.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Final Activity Report Summary - GLYCOGOLD (Exploration of the nature and potential of glyco-nano-particles)

Many signalling and regulation process in our cells depend on very specific recognition of bio-molecules and the specific nature of their interactions. Often carbohydrates (sugar or glycan are largely synonyms) or carbohydrate elements in larger molecules are involved in these mechanisms. Earlier research had provided know-how on methods to prepare nano-particles with a metallic core and specific carbohydrate molecules on the outside. These nano particles have sometimes very interesting properties. The exploration of the potential of gold Glyco-nano-particles (GNPs) has been central in the project. We studied the potential of GNPs as a probe for deepening the understanding of biomolecular interactions and as an instrument to solve biomedical problems. We managed to refine the chemical methods to make tailor made nano-particules where we are now able to include a wide variety of functional molecules to the particle. Functionalised GNPs typically have a metallic core of gold (or of other metals or even semiconductors) covered with multiple spacered carbohydrate ligands. These particles can be tailor made to study and optimise the functioning of the active compound, to include special tags for diagnostic purposes, and to achieve targeted delivery. The following targets have been pursued. 1 To construct well characterised GNPs and their interacting partners. 2 To explore and apply advanced biophysical characterisation methods for GNPs. 3 To explore and apply in-vitro / ex-vivo / in-vivo biomolecular interaction assays. 4 To deepen the understanding of carbohydrate-protein and carbohydrate-carbohydrate biomolecular interactions. 5 To optimise and innovate the design and construction of GNPs. 6 To explore potential biomolecular applications of GNPs. 7 To integrate the results and to draw conclusions on scope and limitations for the use of GNPs.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The aim of the RTN is to explore the potential of gold Glyco-Nano-Particles (GNPs), to deepen the understanding of bio-molecular interactions and to solve biomedical problems. The innovative combination of a variable metallic core with a selected set of ligands can turn GNPs into vaccines or anti-adhesion agents or dedicated vehicles to deliver compounds safely at their target location. GlycoGold will operate as a virtual research-training centre at the interface of physics, chemistry, immunology, molecular biology, and bioinformatics. It integrates and expands the knowledge base and infrastructures of the partners. It has work packages (WPs) that deal with materials, tools and insight into bio-molecular interactions, and WPs geared towards the application of GNPs as vaccines, and control of interactions.The Training&Mobility and Design&Innovation WPs and active networking ensure a smooth project workflow. The tasks are assigned to international task forces. The research is timely, because the required techniques have evolved to a point that an integrated multinational approach is viable. Secondly, interest of industries in obtaining this information is high. Thirdly, the necessary overall knowledge to perform the research in a single laboratory does no t exist in Europe, and very few graduates have the integrated knowledge to operate in this area, despite the large demand for them.The network provides an interdisciplinary training environment for these specialists, where training is offered through:(i) handson experience,(ii) summer schools aimed to bridge the knowledge gap between the physical and life sciences,(iii) short courses, lectures, demonstrations and practical training sessions, and(iv) activities for individual career development.Dedicated international and multilingual science promoting activities are scheduled annually aimed at young science students and in particular at high-school pupils.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз