B-SCATTO · SCATter computed TOmography of the Breast: in vitro" tests and assessment of clinical feasibility"
6РП — Действия „Мария Кюри“
- Период
- 2004-11-01 → 2006-10-31
- Финансиране от ЕС
- 159 613 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Рентгеновата дифракционна томография се тества за разграничаване на различни видове тъкани в гърдата, например здрави клетки от ракови. Методът помага за по-точно описание на биопсиите, тъй като разпознава структури, които изглеждат еднакво при стандартния скенер.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - B-SCATTO (SCATter computed TOmography of the Breast: "in vitro" tests and assessment of clinical feasibility)
The project aimed at assessing the diagnostic capability of X-ray diffraction computed tomography (XRDCT) in its breast imaging application and, in particular, at evaluating its capability of discriminating different types of lesions. Several approaches were considered, combining different detection devices, geometries and X-ray spectra. The most successful approach in terms of information content was an energy-dispersive system based on the use of a spectroscopic, single photon counting detector which allowed complete diffraction patterns to be extracted following the acquisition of low-statistics spectra. This technique allowed to identify several families of diffraction patterns corresponding to different tissue types with different levels of healthy tissue invasion by cancerous cells. The comparison with conventional, i.e. transmission, Computed tomography (CT) showed that, in spite of the poorer spatial resolution, XRDCT allowed for discrimination of structures having the same X-ray attenuation coefficient, hence showing the same average grey level in transmission CT. Furthermore, data acquired with the Energy-dispersive (ED) technique were compared to data obtained with monochromatic synchrotron radiation. Despite the higher intensity of a synchrotron beam EDXRDCT data featured higher information content, thus encouraging the development of laboratory-based techniques rather than techniques based on large facilities. Even though the XRDCT technique was unlikely to be applied 'in vivo' in the immediate future due to the strict constraints in terms of acquisition times and patient dose, it appeared very promising for 'in vitro' tissue characterisation to complete the information provided by breast biopsy. In particular, the dependence of the diffraction signal on the tissue arrangement at the molecular level suggested that EDXRDCT could provide information on changes occurring at the early stages of tumour formation, thus appearing a promising tool for early diagnosis of breast cancer.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The research regards the application of computed tomography to breast scatter imaging for the design of a pre-clinical prototype. The technique is based on the possibility of discriminating normal and neoplastic breast tissue due to their different scattering properties. Hence, it is possible to obtain complementary information with respect to transmission imaging by detecting scattered rather than transmitted radiation.A combination of scatter imaging and computed tomography would provide images with both high contrast and three-dimensional information. Polychromatic and quasi-monochromatic X-ray spectra, the latter obtained by means of a pyrolytic graphite mosaic crystal, would be characterized and used. Images of test objects and of breast tissue samples would be acquired by means of a custom designed set-up, including an X-ray tube, a removable pyrolytic graphite mosaic crystal, a collimation system and a detection device, consisting of one or more detectors for transmission and scatter acquisitions.The most suitable configuration of the system for clinical applications would be determined depending upon image quality, acquisition time and delivered dose. CT reconstruction algorithms and registration techniques would be studied and compared by applying t hem initially to simulated data and later to acquired data. The research would provide the specifications for a pre-clinical set-up for in vivo imaging that would be designed at the end of the work.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY COLLEGE LONDON · LONDONКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз