APAMGNMR · Structural study of magnesium substituted hydroxyapatites by solid state NMR : towards biological and catalytic applications
6РП — Действия „Мария Кюри“
- Период
- 2007-01-01 → 2008-12-31
- Финансиране от ЕС
- 159 046 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Хидроксиапатитите, които са основен компонент на костите, се анализират чрез ядренен магнитен резонанс, за да се види как магнезият променя структурата им. Това помага за по-доброто разбиране на биологичната им роля и създаването на по-ефективни биоматериали и катализатори.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - APAMGNMR (Structural study of magnesium substituted hydroxyapatites by solid state NMR : towards biological and catalytic applications)
Calcium hydroxyapatite (HA), the main inorganic phase of bone tissue, is an important material for bone substitution and other non-medical applications such as catalysis. In natural HA, magnesium (Mg) is one of the main substitutions for calcium. The main objective of this project was to determine the detailed consequences of Mg incorporation on the bulk and surface structure of hydroxyapatites, in order to try to improve understand of its biological role. Solid state nuclear magnetic resonance (NMR) was the key tool utilised in this work, because this technique allowed for the local environment around an atom to be investigated in detail. 25Mg and 43Ca solid state NMR studies were performed on a set of synthetic magnesium-substituted hydroxyapatites, which were used as model samples, and proved, for the first time, that magnesium preferentially entered one of the two positions in the HA crystal structure. In addition, it was shown that proximities between calcium or magnesium cations and neighbouring hydrogen atoms could be investigated in these materials, and that it was possible to analyse their structure in detail at the molecular level. In the long term, this work would enable a more rational elaboration of HA-based functional biomaterials and catalysts, by allowing for better tailoring of their structure, in particular through Mg substitution.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Calcium hydroxyapatite (HA), the main inorganic phase of bone tissue, is an important material for bone substitution and other non-medical applications such as catalysis. In natural HA, magnesium is one of the main substitutions for calcium. Because of its biological relevance, incorporation of Mg in HA has been widely investigated. However, the structural changes caused by Mg substitution remain unclear, and it is crucial these are understood.The main objective of this project is to understand the detailed consequences of Mg incorporation on the bulk and surface structure of magnesium-substituted hydroxyapatites (Mg-HA), in order to explain their bioactivity and reactivity. Solid state Nuclear Magnetic Resonance (NMR) is the key tool, which will be used to provide structural information on a set of Mg-HA samples: for the first time, the environment of each nucleus will be investigated by this technique. Because of the presence magnesium and calcium (two nuclei with small magnetic moments which have been little studied so far), the NMR applied will exploit the very latest techniques, such as very high magnetic fields, double resonance, and multiple quantum and satellite transition magic angle spinning.The substitution-property relationship of the different Mg-HA will then be studied, by investigating the basicity of Mg-HA surfaces, and their biological and catalytic activities. In the long term, this work would enable a more rational elaboration HA-based functional biomaterials and catalysts, by allowing a better tailoring of their activity through Mg substitution. The project is expected to complete and diversify the applicant's expertise by bringing her new technical competences in materials chemistry and solid state NMR, and confronting her with the promising scientific field of appetite-based functional materials. The solid state NMR group in Warwick possesses both the scientific expertise and the state-of-the-art equipment necessary to carry out the project.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF WARWICK · COVENTRYКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз