DIRECTING · Directing traffic - controlling the course of ring forming reactions: Applications in target synthesis
6РП — Действия „Мария Кюри“
- Период
- 2007-01-02 → 2009-01-01
- Финансиране от ЕС
- 160 180 €
- Участници
- 1
- Схема
- EIF
Линиите свързват координатора с партньорите.
Накратко на български
Нови методи за създаване на циклични органични молекули, като азотните хетероцикли, се разработват чрез използването на специални добавки, които контролират формата на продукта. Тези процеси помагат за синтезирането на лекарства и биологично активни вещества за борба с болести.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - DIRECTING (Directing traffic - controlling the course of ring forming reactions: Applications in target synthesis)
Cyclic structural motifs are present in many of the most potent natural biological molecules in addition to various man-made pharmaceutical and agrochemical agents. In fact, cyclic organic molecules have an important role to play in all areas of academic and industrial chemistry. The development of new methods for the construction of cyclic organic molecules is understandably a key area of science. In this organic synthesis project, we developed new, directed cycle-forming or cyclisation, processes that allowed for a range of molecular architectures to be built with excellent control of shape, or stereocontrol. These reactions proceeded using a single reagent with various additives. Crucially, the choice of additive used in a reaction controlled what product was formed. Thus, the additive directed the cyclisation reactions. For example, we developed reactions that made unusual cyclic compounds containing a nitrogen atom, nitrogen heterocycles, and showed the products to be of utility in the preparation of medicines. We also used a new directed cyclisation reaction to build a biologically active naturally-occurring compound. A flexible route to this compound would allow for the preparation of potential therapeutics that were inspired by its structure. These new compounds would be valuable tools for biology and medicine and would assist the fight against disease and illness.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Many of Nature and apos;s most potent molecules have within their structure, a cyclic arrangement of atoms. Similarly, in the chemical industries, cyclic structural motifs are present in many products. In fact, cyclic organic molecules have an important role to play in all areas of life. The development of new ways to construct such molecules in a controlled and selective manner is understandably a key area of chemistry. We will build on recent discoveries from the Manchester group that show a single, acyclic starting material can be `directed down a number of different cyclization pathways by simply changing the alcohol co-solvent used in reactions with the popular reducing agent samarium iodide. These new, stereoselective cyclization reactions allow quick access to a range of molecular architectures found in targets of biological significance that are otherwise not easily made.The project will involve work in several chemical disciplines including, organic synthesis, inorganic/organometallic chemistry, physical organic, and medicinal chemistry. The specific objectives are: - prepare N-heterocyclic frameworks by the cyclization of lactam substrates - assess the generality of the co-solvent `directing phenomenon - develop an asymmetric synthesis of new, cyclic a-amino acids - carry out a `directed, asymmetric synthesis of the core of the biologically active natural product, stolonidiol New organic reactions that allow drugs and other active agents to be constructed rapidly save time and other resources.The principle of making many different products from a common starting material is also economically very attractive. In addition, the work will provide new building-blocks for use in biology and medicine, thus assisting the fight against disease and illness. The project will provide diverse, `tailored training for an excellent European researcher and will lead to scientific results that will enhance the profile of European research.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF MANCHESTER · MANCHESTERКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз