CM-RNA · Comparative Modelling of RNA structures at atomic resolution
6РП — Действия „Мария Кюри“
- Период
- 2006-09-01 → 2008-08-31
- Финансиране от ЕС
- 80 000 €
- Участници
- 1
- Схема
- IRG
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Структурите на РНК молекулите се анализират чрез софтуер, за да се предвиди как те се сгъват в триизмерни форми. Това помага за разбирането на клетъчните процеси и разработването на нови лекарства, които взаимодействат с тези молекули.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - CM-RNA (Comparative Modeling of RNA structures at atomic resolution)
The view of ribonucleic acid (RNA) as a simple information transfer molecule has been continuously challenged since the discovery of the ribozymes, a class of RNA molecules with enzyme-like functions. Moreover, the recent discovery of tiny RNA molecules such as microRNAs and small interfering RNAs is transforming our thinking about how gene expression is regulated. Thus, RNA molecules are now known to carry a large repertory of biological functions within cells, such as transfer of information, enzymatic catalysis and regulation of cellular processes. Similar to proteins, functional RNA molecules fold into specific three-dimensional conformation, which is essential for performing their biological activity. However, our knowledge on the atomic mechanism by which RNA molecules adopt their biological active structures is limited. The ultimate application of a better characterisation of RNA folding is the prediction of their structure. This proposal aimed to develop an RNA structure prediction module within the Modeller program. The application of the method would greatly advance our fundamental knowledge of the relationship between sequence, structure and function of RNA molecules, which was likely to impact various fields of biomedicine, including, but not limited to, the design of new drugs to interact with RNA molecules, the understanding of existing drugs that might be interacting with RNA molecules and the study of how RNA molecules regulated processes at the cellular level. During the first two years of the proposed research, we were able to address three of the four aims of the proposal, which were essential steps for the development of a comparative RNA structure prediction method. We described the RNA structural space by applying a newly developed RNA pair-wise structure alignment method called SARA, which could be found in http://sgu.bionfo.cipf.es/services/SARA/. The alignments generated with the SARA program allowed for the derivation of a set of structural propensities of RNA molecules, which were essential for the recent implementation of an RNA structure prediction method within the Modeller program.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Computational RNA structure prediction is currently limited to secondary structure at the exception of few attempts to predict its 3D conformation. Thus, the problem of predicting the structure of RNA is still unsolved and is part of a major challenge in structural biology: to derive the rules of RNA molecular evolution.This proposal focus on characterizing the underlying principles for comparative modeling of RNA structures at atomic resolution, implementing those principles in a method for comparative modeling, and illustrating its utility. RNA is more like a protein than a DNA because the size, complexity and specific detail of its structure determine its function.Protein comparative modeling is possible because structure is evolutionary more conserved than sequence and because the relationship between sequence and structure can be quantified. At the same time, the number of available protein structures is increasing and sufficient for the derivation of statistical rules for comparative modeling. These requirements are currently meet for comparative modeling of RNA structures.Thus, the challenge for structural computational biologists is to derive the basis for developing an automated, accurate and readily available method for comparative modeling of RN A structures at atomic resolution. The result of this proposal should be such a method, which will be implemented in the MODELLER program currently used at more than 6,000 research institutions worldwide.The application of the method to a large-scale prediction will increase the number of available structures of RNA molecules. Thus, advancing our fundamental knowledge of the relationship between sequence, structure and function of RNA molecules.This is likely to impact various fields of biomedicine, including but not limited to the design of new drugs to interact with RNA molecules and the study of RNA molecules that regulate cellular processes
Оригинален текст от CORDIS (на английски).
Участници
- CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE · VALENCIAКоординаторНиво градИспания
Връзки
Данни: CORDIS, © Европейски съюз