BIOCELLCHARABRX · Biochemical and cell biological characterization of BRX, a novel regulator of root architecture in Arabidopsis, and its role in hormone homeostasis
6РП — Действия „Мария Кюри“
- Период
- 2007-01-01 → 2008-12-31
- Финансиране от ЕС
- 174 965 €
- Участници
- 1
- Схема
- IIF
Линиите свързват координатора с партньорите.
Накратко на български
Генът BRX при растението Arabidopsis регулира развитието на корените и стъблата чрез взаимодействие с растителни хормони. Разбирането на този механизъм може да помогне за повишаване на добива при много други земеделски култури.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - BIOCELLCHARABRX (Biochemical and cell biological characterization of BRX, a novel regulator of root architecture in Arabidopsis, and its role in hormone homeostasis)
The major global challenges in the 21st century, climate change and population growth, are above all challenges to the agricultural sector, as abundant food and natural materials are at the very heart of civilization. They remind us of the need for a sustainable development in agriculture, as it is clear that current productivity levels of crops will not be sufficient if they are to serve more and more people as primary food source, while at the same time they are expected to satisfy emerging accessory needs, such as providing energy in the form of biofuels. Thus, increasing plant productivity is a topic of utmost importance, which can only be addressed by increased research efforts in the plant sciences. In this project, we investigated the molecular mechanisms by which a regulatory gene of the model plant Arabidopsis influences plant growth and development. We generated evidence that this gene is a limiting factor for plant growth through regulating, and responding to plant hormone pathways in an unprecedented molecular manner. It turned out that the protein encoded by this gene initially localizes to the plasma membrane of cells, and only transfers to the nucleus to regulate gene expression if instructed by a certain plant hormone. Although primarily important for root system development, this gene also has a rate-limiting function in shoot growth. As this gene is highly conserved among all higher plant species for which sequencing information is available, our data suggest that our results are applicable to other plants, including all major crops. Thus, eventually, manipulation of the activity level of the corresponding protein in crops might lead to increased yield, a potential application that should follow our research.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
In past years, mutagenesis approaches have proven immensely successful in dissecting the genetics of plant development. While genes that qualitatively affect plant development are very useful for understanding the mechanistic basis of growth and development, these genes appear less likely targets for the evolution of plant morphology than genes that modify the quantitative expression of a trait.Exploiting natural genetic variation enables the detection of alleles that give rise to variation observed within species, which are generally much less characterized than qualitative traits. Natural genetic variation in the model plant Arabidopsis thaliana has been touted as an untapped resource to understand plant genetics and development.The novel Arabidopsis gene, BREVIS RADIX (BRX), was identified using natural variation to isolate regulators that are responsible for intraspecific variation in root system morphology.BRX encodes a protein of unknown function and is the founding member of a small, plant-specific gene family, which is highly conserved among angiosperm species. The primary focus of the proposed research is to elucidate the biochemical, physiological, and cell biological functions of BRX.To this end, my specific aims are to:- determine the role BR X plays in coordination of auxin and brassinosteroid signalling;- understand the regulation and function of the BRX protein; and- define the cell biological and physiological effects of presence or absence of BRX activity by microarray analysis of BRX-inducible lines.The proposed research will result in the first detailed characterization of the biochemical and cell biological function of BRX, the founding member of a novel, plant-specific gene family.Moreover, the brxS mutation provides a unique tool to address how auxin and brassinosteroids exert combinatorial control at the molecular level.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITE DE LAUSANNE · LAUSANNEКоординаторШвейцария
Връзки
Данни: CORDIS, © Европейски съюз