LXRNEUROINFLAMMATION · Anti-inflammatory and anti-apoptotic effects of LXR/RXR agonists in the central nervous system
6РП — Действия „Мария Кюри“
- Период
- 2006-03-15 → 2008-03-14
- Финансиране от ЕС
- 80 000 €
- Участници
- 1
- Схема
- IIF
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Рецепторите LXR и техните активиращи вещества се изследват за влиянието им върху микроглиите, които причиняват възпаления в мозъка при заболявания като множествената склероза. Това помага да се разберат механизмите за защита на нервните клетки и спиране на дегенеративните процеси.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity Report Summary - LXRNEUROINFLAMMATION (Anti-inflammatory and anti-apoptotic effects of LXR/RXR agonists in the central nervous system)
Neuroinflammation is a characteristic of pathological affected tissue in several neurodegenerative disorders, such as multiple sclerosis and intervention of the inflammatory process has gained attention as a therapeutic strategy to halt neurodegenerative disorders. One of the primary cell types in the central nervous system that contributes to neuroinflammation is microloglia, originally derived from monocytes/macrophages. We have been studying the role of two transcription factors from the nuclear receptor superfamily, LXRalpha and beta, in microglial activation in response to cytokines produced at the inflammatory site. Recent findings support a protective role for LXRs in experimentally-induced diseases with a neuroinflammatory origin, such as murine experimental autoimmune encephalomyelitis, although the mechanisms that allow neuroprotection are not completely understood. Using gene profiling studies we have determined a subset of cytokine-regulated genes that are susceptible to down regulation by agonists for LXR. In parallel, we have also determined a number of parameters of microglial function, such as proliferation, the production and release of pro-inflammatory mediators and their ability to phagocytose apoptotic bodies that are affected by LXR activation. Several lines of research have been initiated in order to understand the mechanism/s by which LXRs interfere with the different pathways of microglia activation, including signal transduction pathways and factors that directly transcriptional machinery. Furthermore, we have also analysed direct and indirect effects of LXR activation on survival of neuronal cells under different conditions of stress. The results of these studies are currently being organised for publication.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The goal of this project is to study the role of the nuclear receptor LXR (Liver X Receptor) in neuro-inflammation and neuro-degeneration. Nuclear receptors are ligand-dependent transcription factors capable of activating or repressing gene expression. Recent studies performed by the principal investigator at the University of California San Diego and by other groups have implicated LXR in the modulation of immune responses. The work proposed here will study whether LXR agonists exert effects on microglia activation, proliferation and programmed cell death in the context of neuro-inflammation.One of the LXR target genes recently discovered by the principal investigator is an anti-apoptotic factor, AIM, specifically secreted by certain macrophage populations. W e are interested in determining whether LXR agonists promote release of this factor in the central nervous system and whether this pathway is relevant to protect neuronal cell death. By using gene expression profiling methodologies we will explore the transcriptional programs that are regulated by LXR in the context of neuro-inflammation. In vivo experiments in animal models of neuro-inflammation will provide an insight of whether LXR agonists may be used for therapeutic intervention of neuro-degenerative disorders.
Оригинален текст от CORDIS (на английски).
Участници
- INSTITUT DE RECERCA BIOMÈDICA DEL PARC CIENTÍFIC DE BARCELONA · BARCELONAКоординаторНиво градИспания
Връзки
Данни: CORDIS, © Европейски съюз