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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
FP6Докторантска мрежа2007–2011

PENELOPE · Evolution of the Protein-Interaction Networks: the SH3 network in Yeast

6РП — Действия „Мария Кюри“

Период
2007-04-01 → 2011-03-31
Финансиране от ЕС
2 900 000 €
Участници
7
Схема
RTN

Линиите свързват координатора с партньорите.

Накратко на български

Протеиновите мрежи при четири вида дрожди, по-конкретно тези с SH3 домени, се анализират, за да се види как се променят във времето. Това помага за разбирането на молекулните механизми в клетките и причините за възникване на различни заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Final Activity Report Summary - PENELOPE (Evolution of the Protein-Interaction Networks: the SH3 network in Yeast)

Penelope, the faithful wife of Ulysses in Homer's Odyssey, wove and un-wove a shroud while awaiting the return of her husband. Taking inspiration from the Greek epic, researchers in the Penelope project are unravelling the complicated web of proteins that make up the cells of living organisms in an attempt to understand the underlying causes of health and diseases. Penelope recruited overall 19 young researchers from 14 different nationalities for whom the project marked a first plunge into multi-disciplinary basic research. All got the opportunity to lay the building blocks for further discovery of how living things operate at the most basic level. At the same time, they were offered multiple tools and training to develop further their career, their skills and their knowledge. In particular, the Penelope researchers are studying protein interactions in yeast strains as a means of shedding light on the fundamental molecular mechanisms of cellular networks. Nowadays, after the deciphering of the human genome and the advent of "omics" technologies, we know the components of living systems. The next challenge is to understand their interactions. The Penelope spotlight is focused firmly on four yeast species whose cellular structures have evolved over thousand million years. The researchers have characterized their protein interaction networks, specifically those mediated by the Sarc-homology-3 (SH3) domains, whilst looking out for any previously undetected ones. Commonly found in the eukaryotic genomes, SH3 protein networks are involved in many fundamental biological processes, such as cell signalling and regulation. Comparative analysis across the four genomes allows to investigate how new interactions were added to their networks as well as how others were lost over time. Overall, Penelope has contributed in giving new insights into several biological processes and how they have evolved. A major final collaborative effort is on-going and will be submitted for publication at the end of 2011.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The overall goal of this Research Training Network (RTN) is to gain a quantitative understanding of the nature and evolution of protein interaction networks in eukaryotes. This will require the application of a broad range of methods and technologies, thus providing a unique opportunity for interdisciplinary training of early-stage and experienced researchers.The RTN focuses on the study of the interplay between Src Homology 3 (SH3) domains, their host proteins and their binding partners (or target ligands) in four different yeast species, i.e. Saccharomyces cerevisiae (the best studied eukaryotic cell which exclusively profilerates by budding), Candida albicans (a human pathogen able to switch between bud-like and hyphal growth), Ashbya gossypii (a plant p athogen which exclusively grows like filamentous fungus), and Schizosaccharomyces pombe (the second best studied yeast which profilerates by bipolar growth and fission). These yeasts encompass a thousand million years of evolution.The RTN intends to characterize the presently known interactions and to identify hitherto undetected interactions. Comparative analyses across the four genomes will allow us to investigate how new interactions were added to a network to cope with new necessities, as well as how t hey were lost when they were not needed anymore. The RTN will train researchers to be able to use a combination of approaches ranging from structural biology, biochemistry, genetics and genomics to advanced light microscopy and simulation tools for cell networks. To achieve these objectives a multidisciplinary approach will be carried out, by bringing together the expertise of leading research groups at a multilateral level.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз