LUNAMICE · Soy-peptide Lunasin as potential colon cancer preventive agent
6РП — Действия „Мария Кюри“
- Период
- 2007-01-20 → 2009-06-19
- Финансиране от ЕС
- 255 187 €
- Участници
- 2
- Схема
- OIF
Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.
Накратко на български
Лунасинът е протеин от соеви зърна, който се изследва за способността си да спира растежа на ракови клетки, например при рак на гърдата и дебелото черво. Това помага за разбирането на механизмите за предотвратяване на тумори и възможностите за комбиниране на терапии.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Final Activity and Management Report Summary - LUNAMICE (Soy-peptide Lunasin as potential colon cancer preventive agent)
Lunasin is a peptide identified in soybean and other seeds and plants by Prof. de Lumen in 1997. This peptide has demonstrated to exert chempopreventive properties by in vitro and in vivo assays. During my stay at the University of California, Berkeley, I conducted different studies focused on evaluating these properties against breast cancer as well as on elucidating lunasin's mechanism of action. We have demonstrated that lunasin inhibits cell proliferation, arrests cell cycle and induces apoptosis in human breast cancer MDA-MB-231 cells. Lunasin seems to modulate expression of different genes and proteins involved in cell cycle, apoptosis and signalling transduction in these cells. Moreover, an epigenetic mechanism of action has been revealed. Lunasin acts inhibiting histones H3 and H4 acetylation. This peptide has also been found to inhibit cell growth of fibroblast cells induced by chemical carcinogens. An interesting result from the studies conducted at Prof. de Lumens' group has been founding that lunasin potentates aspirin's effects against breast cancer. Combination lunasin/aspirin is shown as a promising strategy against mamary tumour, although new experiments with animal models and human trials should be needed to confirm these results. In summary, lunasin is becoming an important peptide with promising cancer preventive properties. In addition to those effects desmonstrated during my stay at UC Berkeley, different international groups have reported lunasin's effects against colon cancer and leukaemia, opening a new door for future studies focused on determining these effects against other types of cancer.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The dietary factors play an important role in the ethiology of cancer. An inverse association between colorectal cancer and the soy consumption has been reported. Several compounds contained in soybean protein have been described as cancer preventive agent s. One of these compounds, which is named Lunasin, was discovered of serendipitous manner by Prof. de Lumen's group.The first results obtained from in vitro studies have provided a promising future for this peptide as basis of new nutraceutical products derived from a food source. However, multidisciplinary analyses should be needed to confirm these preliminary results. These analyses will be carried out during the performance of the proposed project LUNAMICE". This project aims to test the efficacy of Lunasin to delay or prevent the development of colon tumours and determine its chemopreventive mechanism of action. The first objective of this project is increasing the yield of the Lunasin production by optimising and applying different immunoanalytical, chromatographic and electrophoretic techniques. Obtaining Lunasin in high amounts will allow carrying out the following bioavailability assays as well as the proposed nutritional studies with different carcinogenic animal models.Finally, the project aims to determine the action mechanism of Lunasin by several differential expression studies. The data should result in the revelation of potential surrogate biomarkers such as epigenetics and chromation modifications associated with colon cancer formation. This multidisciplinary project will provide the candidate with a high knowledge of food chemistry and biochemistry, nutrition, proteomics and genomics, and will contribute to her complementary skills. The benefits gained will be the final requirements for becoming an independent and mature professional in food, nutrition and biosciences. All this experience acquired by the researcher will be very helpful for her scientific career once she comes back at Spain."
Оригинален текст от CORDIS (на английски).
Участници
- CONSEJO SUPERIOR DE INVESTIGACIONES CIENT?-FICAS · MADRIDКоординаторИспания
- UNIVERSITY OF CALIFORNIA, BERKELEY · BERKELEYНиво градСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз